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Merck
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主要文件

SAB4501401

Sigma-Aldrich

Anti-HMGB1 antibody produced in rabbit

affinity isolated antibody

别名:

HMG-1, HMG1, High mobility group protein 1, High mobility group protein B1

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 24 kDa

物種活性

rat, human, mouse

濃度

~1 mg/mL

技術

ELISA: 1:20000
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... HMGB1(3146)

一般說明

Anti-HMGB1 Antibody detects endogenous levels of total HMGB1 protein.
High mobility group box 1 (HMGB1) is a nuclear protein that belongs to the damage-associated molecular pattern (DAMP) family. It is located on human chromosome 13q12.

免疫原

The antiserum was produced against synthesized peptide derived from human HMGB1.

Immunogen Range: 131-180

生化/生理作用

High mobility group box 1 (HMGB1) is involved in bone remodeling and ectopic calcification pathogenesis. It initiates neuroinflammation after epileptogenic injuries. HMGB1 also binds to chromatin and modulates gene transcription.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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访问文档库

Roles of High Mobility Group Box 1 in Cardiovascular Calcification.
Chen Q, et al.
Cellular Physiology and Biochemistry, 42(2), 427-440 (2017)
A new case of 13q12.2q13.1 microdeletion syndrome contributes to phenotype delineation.
Mandrile G,et al.
Case Reports in Genetics (2014)
Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.
Walker LE, et al.
The Journal of Clinical Investigation, 127(6), 2118-2132 (2017)
Laura Patricia Whittall-Garcia et al.
Lupus science & medicine, 11(1) (2024-01-05)
To determine if the serum levels of neutrophil extracellular trap (NET) remnants (Elastase-DNA and HMGB1-DNA complexes) at the time of a lupus nephritis (LN) flare predict renal outcomes in the following 24 months. This was a retrospective study performed in

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