推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
100 kDa
种属反应性
rat, human, mouse
浓度
1.0 mg/mL
技术
western blot: 1:500-1:1000 (Cell Lysate)
同位素/亚型
IgG
登记号
NP_001070962.1
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer872)
基因信息
human ... NFKB2(4791)
一般描述
Nuclear factor kappa B subunit 2 (NFKB2) encodes the nuclear factor kappa B2 (NF-κB), a nuclear transcription factor. NF-κB is evolutionarily highly conserved. In human chromosome, the gene NFKB2 is localized on 10q24.
特异性
The antibody detects endogenous level of NF-κB p100 only when phosphorylated at serine 872.
免疫原
Peptide sequence around phosphorylation site of serine872(S-Q-S(p)-V-E) derived from Human NF-κB p100 .
生化/生理作用
Regulation of nuclear factor kappa B subunit 2 (NFKB2) includes cytoplasmic-nuclear shuttling and its transcriptional activity. NF-κB plays a key role in regulating the immune response and apoptotic processes. It is necessary for combating diseases like arthritis, autoimmune diseases and asthma. Mutations in NFKB2 impairs post translational processing of p100 preventing nuclear translocation of p52. This leads to common variable immunodeficiency and adrenal insufficiency. Mutation also affects canonical and non-canonical pathway of NFKB2 signalling and causes autosomal dominant primary antibody deficiency (PAD). chromosomal aberrations in C-terminal region of NFKB2 is associated lymphoid malignancies.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Analysis of NFKB2-mediated regulation of mechanisms underlying the development of Hodgkin's lymphoma
Zhang Y, et al.
Molecular Medicine Reports, 17(6), 8129-8136 (2018)
Mutations in NFKB2 and potential genetic heterogeneity in patients with DAVID syndrome, having variable endocrine and immune deficiencies
Brue T, et al.
BMC Medical Genetics, 15(1), 139-139 (2014)
Missing pieces in the NF-kappaB puzzle
Ghosh S and Karin M
Cell, 109(2), S81-S96 (2002)
Germline mutations in NFKB2 implicate the noncanonical NF-?B pathway in the pathogenesis of common variable immunodeficiency.
Chen K
American Journal of Human Genetics, 93(5), 812-824 (2013)
Autosomal dominant B cell deficiency with alopecia due to a mutation in NFKB2 that results in non-processible p100
Lee CE, et al.
Blood, 124(5), 2964-2972 (2014)
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