SAB4300456
Anti-EFNB2 (Ab-330) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-EPLG5 antibody produced in rabbit, Anti-HTKL antibody produced in rabbit, Anti-Htk-L antibody produced in rabbit, Anti-LERK5 antibody produced in rabbit, Anti-ephrin-B2 antibody produced in rabbit
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About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
~37 kDa
物種活性
rat, mouse, human
濃度
1 mg/mL
技術
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同型
IgG
免疫原序列
(N-I-Y-Y-K)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... EFNB2(1948)
一般說明
EFNB2 (ephrin B2) is a membrane-bound molecule , that is located on human chromosome 13q33.
免疫原
Peptide sequence around aa. 328-332 (N-I-Y-Y-K), according to the protein EFNB2.
生化／生理作用
EFNB2 (ephrin B2) regulates the development of arterial endothelial cell. It also modulates the movement and adherence of vascular smooth muscle cells and pericytes to the extending arterial endothelial cell tubes. Overexpression of EFNB2 results in low tumor stage and elevated expression of TrkA in neuroblastomas. It controls the growth of thymocyte and differentiation of peripheral T cell. It is required for interleukin-6 (IL-6) signaling. It also modulates the antiviral immune responses.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
標靶描述
Ephrin-B2 encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a lycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.
外觀
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Association analysis of the ephrin-B2 gene in African-Americans with end-stage renal disease
Hicks PJ, et al.
American Journal of Nephrology, 28(6), 914-920 (2008)
High-level expression of EPHB6, EFNB2, and EFNB3 is associated with low tumor stage and high TrkA expression in human neuroblastomas
Tang XX, et al.
Clinical Cancer Research, 5(6), 1491-1496 (1999)
Efnb1 and Efnb2 proteins regulate thymocyte development, peripheral T cell differentiation, and antiviral immune responses and are essential for interleukin-6 (IL-6) signaling
Luo H, et al.
The Journal of Biological Chemistry, 286(48), 41135-41152 (2011)
Jaeho Yoon et al.
Nature communications, 9(1), 3491-3491 (2018-08-30)
Although Eph-ephrin signalling has been implicated in the migration of cranial neural crest (CNC) cells, it is still unclear how ephrinB transduces signals regulating this event. We provide evidence that TBC1d24, a putative Rab35-GTPase activating protein (Rab35 GAP), complexes with
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