SAB4300253

Anti-phospho-SMAD3 (pSer⁴²⁵) antibody produced in rabbit

affinity isolated antibody

• 别名: Anti-DKFZp586N0721 antibody produced in rabbit, Anti-DKFZp686J10186 antibody produced in rabbit, Anti-HSPC193 antibody produced in rabbit, Anti-HsT17436 antibody produced in rabbit, Anti-SMAD family member 3 antibody produced in rabbit
• 分類程式碼代碼: 12352203
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: ~52 kDa
• 物種活性: mouse, human, rat
• 濃度: 1 mg/mL
• 技術: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
• 同型: IgG
• 免疫原序列: (C-S-S-V-SP)
• NCBI登錄號: NP_001138574.1
• UniProt登錄號: P84022
• 應用: research pathology
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: phosphorylation (pSer425)
• 基因資訊: human ... SMAD3(4088)

说明

一般說明

The SMAD3 (mothers against decapentaplegic homolog 3) gene is mapped to human chromosome 15q22.33. Smad3 protein identifies tandem repeats of the palindromic sequence GTCTAGAC, which is part of TGF-β (Transforming growth factor β) signaling promoter region.

免疫原

Peptide sequence around phosphorylation site of serine 425 (C-S-S-V-S(p)), according to the protein SMAD3.

應用

Anti-phospho-SMAD3 (pSer425) antibody produced in rabbit has been used in immunoblotting.

生化／生理作用

Smad3 (mothers against decapentaplegic homolog 3) is associated with TGF-β (transforming growth factor β) signaling pathway, a cellular process regulating the homeostasis, development, and repair of cartilage. It is known to induce extracellular matrix production. Smad proteins are responsible for the transduction of signals from cell surface to the nucleus. Phosphorylation of Smad3 controls tumor progression, inflammation, fibrosis, obesity and diabetes. Smad3 expression might be associated with the pathogenesis of osteoarthritis.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

標靶描述

Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

外觀

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable