SAB4200840
Anti-Pro LC3C antibody, Mouse monoclonal
clone BTY-1, purified from hybridoma cell culture Affinity isolated antibody
别名:
Autophagy-related protein LC3 C, Autophagy-related ubiquitin-like modifier LC3 C, MAP1 light chain 3-like protein 3, MAP1A/MAP1B LC3 C, MAP1A/MAP1B light chain 3 C, Microtubule-associated protein 1 light chain 3 gamma, Microtubule-associated proteins 1A/1B light chain 3C
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About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
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生物源
mouse
抗體產品種類
primary antibodies
無性繁殖
BTY-1, monoclonal
形狀
liquid
物種活性
human
包裝
antibody small pack of 25 μL
濃度
~1 mg/mL
技術
immunoblotting: 0.5-1 μg/mL using whole extracts of HEK-293T cells overexpressing human LC3C
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... MAP1LC3C(440738)
相关类别
一般說明
Monoclonal Anti-Pro LC3C antibody (mouse IgG1 isotype) is derived from the BTY-1 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse. Human microtubule-associated proteins 1 light chain 3 (LC3C) is an ortholog of yeast Atg8. It is expressed in different human tissues. LC3C belongs to the subfamily of LC3 and the family of human Atg8. It is a structural protein of the autophagosomal membrane. LC3C gene is located on the human chromosome at 1q43.
特異性
Monoclonal Anti-Pro LC3C antibody specifically recognizes epitope at the C-terminal pro-peptide domain of human LC3C-I and/or LC3C-II and dose not cross react with human LC3A or LC3B.
免疫原
Synthetic peptide corresponding to the C-terminal region of human LC3C, conjugated to KLH
應用
Anti-Pro LC3C antibody, mouse monoclonal may be used in immunoblotting and immunofluorescence.
生化／生理作用
Human microtubule-associated proteins 1 light chain 3 (LC3C) protein is considered as an autophagy marker. It enhances the trafficking of hepatocyte growth factor (Met) receptor tyrosine kinase (RTK) to an autophagic compartment. LC3C protein also plays a role in antibacterial autophagy.
外觀
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
儲存和穩定性
For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免責聲明
Unless otherwise stated in our catalog our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Autophagosome proteins LC3A, LC3B and LC3C have distinct subcellular distribution kinetics and expression in cancer cell lines
Koukourakis M I, et al.
PLoS ONE, 10(9), e0137675-e0137675 (2015)
LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion
Bell E S, et al.
Testing, 29(12), 4053-4068 (2019)
Natalia von Muhlinen et al.
Molecular cell, 48(3), 329-342 (2012-10-02)
Autophagy protects cellular homeostasis by capturing cytosolic components and invading pathogens for lysosomal degradation. Autophagy receptors target cargo to autophagy by binding ATG8 on autophagosomal membranes. The expansion of the ATG8 family in higher eukaryotes suggests that specific interactions with
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