推荐产品
生物源
mouse
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
4A4, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~72 kDa
物種活性
human
加強驗證
independent
Learn more about Antibody Enhanced Validation
濃度
~1.0 mg/mL
技術
indirect immunofluorescence: 0.25-0.5 μg/mL using human HeLa cells
western blot: 0.25-0.5 μg/mL using whole extracts of human HeLa cells
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... LMNA(4000)
一般說明
Lamin A is encoded by the gene with exons 1–12, mapped on human chromosome 1q21-22. The encoded protein is a major component of the inner nuclear membrane lamina. Lamin A is expressed in variety of tissues, including adult heart and skeletal muscle.
免疫原
synthetic peptide corresponding to the C-terminus of mature human Lamin A.
應用
Monoclonal Anti-Lamin A, mature antibody produced in mouse has been used in immunohistochemistry.
生化／生理作用
Lamin A can be used as a biomarker for cancer diagnosis and prognosis. It also plays a major role in maintaining cardiac homeostasis. Mutation in the gene is associated with Emery-Dreifuss muscular dystrophy (EDMD-AD) and Hutchinson–Gilford progeria syndrome (HGPS). In addition, variation in the gene expression also leads to various disorders such as, lipodystrophy, progeria, muscular dystrophy, neuropathy and cardiomyopathy.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Increased ventilatory response to exercise in symptomatic and asymptomatic LMNA mutation carriers: a follow-up study.
Ollila L
Clinical Physiology and Functional Imaging, 37, 8-16 (2017)
Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease
Fatkin D
The New England Journal of Medicine, 341, 1715-1724 (1999)
Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy.
Cao H and Hegele RA
Human Molecular Genetics, 9, 109-112 (2000)
Juvenile-onset generalized lipodystrophy due to a novel heterozygous missense LMNA mutation affecting lamin C.
Patni N
American Journal of Medical Genetics. Part A, 173, 2517-2521 (2017)
Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status.
Kaspi E
PLoS ONE, 12 (2017)
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