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Merck

S8809

Sigma-Aldrich

Pan单克隆抗 钠通道 小鼠抗

~1 mg/mL, clone K58/35, purified immunoglobulin

别名:

Sodium Channel Antibody

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

K58/35, monoclonal

物種活性

mammals

濃度

~1 mg/mL

技術

immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1 μg/mL using sciatic and optic nerve sections; cultured hypocampal neurons
western blot: 1 μg/mL using crude brain membrane prep (rat)

同型

IgG1

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

一般說明

电压门控钠通道/VGSCs(Nav)是由膜的去极化启动的跨膜蛋白。它们是具有大的成孔 α-亚基和小的 β-亚基的异质多聚体。

特異性

该克隆识别的序列在所有已知脊椎动物的 Na + 通道中是相同的。在培养的海马神经元中,该抗体可特异性染色轴突起始段。在坐骨神经和视神经中,它可染色郎飞结。

免疫原

来自细胞内 III-IV Na + 通道环的合成肽 CTEEQKKYYNAMKKLGSKK

應用

小鼠单克隆抗钠通道泛抗体可用于:
  • 免疫组化(1:50)
  • 免疫染色(1:200)
  • 免疫荧光
  • 免疫细胞化学(1:100)

生化/生理作用

电压门控钠通道/VGSCs(Nav)参与伤害性传导。它们在调节胞外和胞内空间之间的交换方面发挥着关键作用。VGSC 对于动作电位的启动和激发至关重要。它们参与神经元的兴奋性。因此,VGSC 基因的突变会导致几种癫痫疾病。

外觀

溶液含 10 mM Tris (pH 7.5)、 0.1 mNaCl、30% 甘油和 15 mM 叠氮化钠。

法律資訊

由SUNY Stony Brook 独家授权销售。

免責聲明

除非我们的产品目录或产品随附的其他公司文件中另有说明,否则我们的产品仅用于研究用途,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。

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