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品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
yellow
溶解度
DMSO: >10 mg/mL
H2O: insoluble
起源
GlaxoSmithKline
儲存溫度
2-8°C
SMILES 字串
O.Cl.Cc1cccc(n1)-c2[nH]c(nc2-c3ccc4OCOc4c3)C(C)(C)C
InChI
1S/C20H21N3O2.ClH.H2O/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15;;/h5-10H,11H2,1-4H3,(H,22,23);1H;1H2
InChI 密鑰
DIDCCMVWCVRTNB-UHFFFAOYSA-N
應用
SB-505124盐酸盐水合物可用于研究TGF-β途径在发育和分化研究中的作用。3,4
生化／生理作用
SB-505124可选择性抑制TGF-βⅠ型受体，以及激活素受体样激酶（ALK）4、5和7。它可抑制ALK4-、5-和7-介导的TGF-β诱导的Smad2、Smad3和MAPK通路的激活。1 SB-505124可抑制由与食道鳞状细胞癌共培养所诱导的人成纤维细胞的转分化。2
SB-505124是一种激活素受体样激酶（ALK）5的抑制剂，也被称为转化生长因子-α Ⅰ型受体激酶，其IC50 为47±5 nM。
特點和優勢
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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