S0278

(±)-索他洛尔 盐酸盐

≥98% (TLC), powder, β-Adrenoceptor antagonist

• 别名: N-[4-[1-羟基-2-（异丙基氨基）乙基]苯基]甲磺酰胺 盐酸盐
• 经验公式（希尔记法）: C₁₂H₂₀N₂O₃S · HCl
• CAS号: 959-24-0
• 分子量: 308.82
• EC 号: 213-496-0
• MDL编号: MFCD00242937
• UNSPSC代码: 12352200
• PubChem化学物质编号: 24278689
• NACRES: NA.77

属性

• 产品名称: (±)-索他洛尔 盐酸盐, ≥98% (TLC), powder
• 质量水平: 200
• 方案: ≥98% (TLC)
• 表单: powder
• 颜色: white to off-white
• 溶解性: H₂O: 20 mg/mL
• 创始人: Bayer
• SMILES字符串: Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1
• InChI: 1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
• InChI key: VIDRYROWYFWGSY-UHFFFAOYSA-N
• 基因信息: human ... ADRB1(153) , ADRB2(154) , ADRB3(155) , KCNH2(3757)

说明

应用

(±)-Sotalol hydrochloride has been used to test its effect on the cardiac action potential (AP) in human hearts. It has also been used as an β- blocker to determine its effect on free intracellular calcium (Ca²⁺) release and whole-cell currents in mammalian cancer cells.

生化/生理作用

Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.

Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: dust mask type N95 (US), Eyeshields, Gloves