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物種活性
human
包裝
kit of 96 wells (12 strips x 8 wells)
技術
ELISA: suitable
輸入
sample type plasma
sample type cell culture supernatant(s)
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.41 ng/mL
standard curve range: 0.410-100 ng/mL
檢測方法
colorimetric
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... ST14(6768)
一般說明
The ST14 (suppression of tumorigenicity 14) gene encodes a cell surface serine protease which is also called as matriptase. The ST14 gene is mapped to human chromosome 11q24.3.
This ELISA antibody pair detects Human Matriptase. Other species not yet determined.
應用
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
生化／生理作用
St14 (suppression of tumorigenicity 14) forms complexes with serine proteases inhibitors HAIs (hepatocyte growth factor activator inhibitors), to prevent its proteolytic activity. ST14 expression is required for epithelial mesenchymal transition in tumor cells. St14′s biological activity is specific to different substrates, which includes extracellular matrix proteins, hepatocyte growth factor, epidermal growth factor receptor (EGFR), adhesion molecules including Mac25 (insulin-like growth factor-binding protein 7) and Tie2 (angiopoietin-1 receptor) , proteases including urokinase plasminogen activator (uPA), prostasin (PRSS8), matrix metalloprotease 3 (MMP3). Upregulation of the gene is found in progressed epithelial cancer but lower expression of the gene is observed in colon cancer and hence it is termed ‘suppression of tumors′.
其他說明
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
訊號詞
Warning
危險聲明
防範說明
危險分類
Met. Corr. 1
儲存類別代碼
8A - Combustible corrosive hazardous materials
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Activation of proHGF by St14 induces mouse embryonic stem cell differentiation.
Yan X, et al.
Protein & cell, 7(8), 601-605 (2016)
Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase.
Basel-Vanagaite L, et al.
American Journal of Human Genetics, 80(3), 467-477 (2007)
Impact of suppression of tumorigenicity 14 (ST14)/serine protease 14 (Prss14) expression analysis on the prognosis and management of estrogen receptor negative breast cancer.
Kim S, et al.
Oncotarget, 7(23), 34643-34643 (2016)
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