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Merck
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RAB0235

Sigma-Aldrich

人类 IGFBP-3 ELISA 试剂盒

for serum, plasma, cell culture supernatant and urine

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About This Item

分類程式碼代碼:
41116158
NACRES:
NA.32

物種活性

human

包裝

kit of 96 wells (12 strips x 8 wells)

技術

ELISA: suitable
capture ELISA: suitable

輸入

sample type plasma
sample type serum
sample type cell culture supernatant(s)
sample type urine

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/mL
standard curve range: 74.07-18000 pg/mL

檢測方法

colorimetric

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... IGFBP3(3486)

一般說明

The Human IGFBP-3 ELISA (Enzyme-Linked mmunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human IGFBP-3 in serum, plasma, cell culture supernatants and urine.

免疫原

Recombinant Human IGFBP3

應用

请参考Protocol了解详情。

生化／生理作用

Insulin-like growth factor-binding protein 3 (IGFBP3) is implicated in cell survival. In addition, it also facilitates cell death and tumorigenesis. Epigenetic changes in IGFBP3 affect non-small-cell lung cancer, hepatocellular carcinoma, ovarian cancer, skin cancer, urological cancers, breast cancer and gastric cancer. IGFBP3 is a primary growth inhibitor and can reverse the mitogenic functions of IGF-1 (insulin like growth factor 1) by inducing apoptosis.

其他說明

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

试剂盒组分也可单独购买

产品编号
说明
化学品安全说明书
  • RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)化学品安全说明书
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)化学品安全说明书
  • RABSTOP3ELISA Stop Solution (Item I)化学品安全说明书
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)化学品安全说明书
  • RABWASH420X Wash Buffer (Item B)化学品安全说明书

象形圖

Corrosion
GHS05

訊號詞

Warning

危險聲明

H290

防範說明

P234 - P390

危險分類

Met. Corr. 1

儲存類別代碼

8A - Combustible corrosive hazardous materials

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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访问文档库

The low IGFBP-3 level is associated with esophageal cancer patients: a meta-analysis.
Song G, et al.
World Journal of Surgical Oncology, 14(1), 307-307 (2016)
Insulin-like growth factor binding protein-3 mediates interleukin-24-induced apoptosis through inhibition of the mTOR pathway in prostate cancer.
Du Y, et al.
Oncology, 34(5), 2273-2281 (2015)
Evaluation of Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 Expression Levels in Patients with Chronic Lymphocytic Leukemia.
Ayer M, et al.
Turkish journal of haematology : official journal of Turkish Society of Haematology, 33(4), 335-335 (2016)
Yan Wang et al.
Medical oncology (Northwood, London, England), 31(5), 921-921 (2014-03-29)
Growth factors in the brain are important to depression. We investigated the relationship between serum insulin-like growth factor (IGF-1) and IGF-binding protein-3 (IGFBP-3) concentration and risk of depression and the effect of psychological intervention on outcomes of high-grade glioma patients
Francesca D'Addio et al.
Nature communications, 13(1), 684-684 (2022-02-05)
Loss of pancreatic beta cells is a central feature of type 1 (T1D) and type 2 (T2D) diabetes, but a therapeutic strategy to preserve beta cell mass remains to be established. Here we show that the death receptor TMEM219 is

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