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About This Item
经验公式（希尔记法）:
C18H13N3O
CAS号:
分子量:
287.32
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.25
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品質等級
化驗
>98% (HPLC)
形狀
solid
顏色
white
溶解度
DMSO: soluble 18 mg/mL (clear yellow solution)
H2O: insoluble
儲存溫度
2-8°C
SMILES 字串
O=C1N2CCc3c([nH]c4ccccc34)C2=Nc5ccccc15
InChI
1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2
InChI 密鑰
ACVGWSKVRYFWRP-UHFFFAOYSA-N
基因資訊
human ... CYP1A1(1543) , CYP1A2(1544) , CYP1B1(1545)
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生化／生理作用
延迟整流 K + 通道阻滞剂。抑制血小板聚集；输精管扩张器。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Máté Bubenyák
Acta pharmaceutica Hungarica, 81(4), 139-149 (2012-02-15)
Quinazolinocarboline rutaecarpine and evodiamine (Evodia rutaecarpa) are main alkaloid components of traditional Chinese folk-remedies. Evodiamine exhibited selective antitumor and antimetastatic effects on several cancer cell lines and became lead structure of anticancer agents. During our synthetic research we achieved to
Chuan-Qin Hu et al.
Journal of Asian natural products research, 14(7), 634-639 (2012-05-16)
A new natural product, 10-hydroxyrutaecarpine (1), and a rarely new glycosidic alkaloid, rutaecarpine-10-O-rutinoside (2), along with the known compounds rutaecarpine (3), evodiamine, wuzhuyuamide-I, and dehydroevodiamine were isolated from the butanol fraction of 70% ethanol aqueous extract of the dried and
Seung Ill Kim et al.
Archives of pharmacal research, 35(5), 785-789 (2012-05-31)
A series of rutaecarpine derivatives were prepared by employing previously reported methods and their inhibitory activities against topoisomerase I and II were evaluated. Among them, strongly cytotoxic 10-bromorutaecarpine and 3-chlororutaecarpine showed strong inhibitory activities against topo I and II.
S N Wu et al.
Neuropharmacology, 41(7), 834-843 (2001-10-31)
The effects of rutaecarpine on ionic currents of NG108-15 neuronal cells were investigated in this study. Rutaecarpine (2-100 microM) suppressed the amplitude of delayed rectifier K+ current (I(K(DR))) in a concentration-dependent manner. The IC50 value for rutaecarpine-induced inhibition of I(K(DR))
Jian-Zhe Li et al.
Canadian journal of physiology and pharmacology, 88(10), 949-959 (2010-10-22)
Dysfunction of capsaicin-sensitive sensory nerves is involved in cardiac remodeling, and rutaecarpine has been shown to exert a beneficial effect on cardiac function through activating the sensory nerves. This study was conducted to explore the potential inhibitory effect of rutaecarpine
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