P4670

普罗帕酮 盐酸盐

• 别名: 1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride
• 经验公式（希尔记法）: C₂₁H₂₇NO₃ · HCl
• CAS号: 34183-22-7
• 分子量: 377.90
• EC號碼: 251-867-9
• MDL號碼: MFCD00079243
• 分類程式碼代碼: 41116107
• PubChem物質ID: 24278636
• NACRES: NA.77

属性

• 形狀: powder
• 品質等級: 100
• 起源: Abbott
• 儲存溫度: 2-8°C
• SMILES 字串: Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2
• InChI: 1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
• InChI 密鑰: XWIHRGFIPXWGEF-UHFFFAOYSA-N
• 基因資訊: human ... ABCB1(5243) , ADRB1(153) , ADRB2(154) , ADRB3(155) , CYP1A2(1544) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

说明

一般說明

Propafenone hydrochloride is a calcium antagonist. It functions as a Na⁺ and K⁺ channel blocker. It might be used to treat patients with systemic hypertension. Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver. Propafenone hydrochloride is used to treat ventricular arrhythmias.

應用

Propafenone hydrochloride has been used in the isolation of cardiomyocytes.

生化／生理作用

Blocks hKv1.5 and ATP-sensitive K⁺ channels; class 1C antiarrhythmic agent that is also an antagonist at β adrenergic receptors.

特點和優勢

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3