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About This Item
经验公式（希尔记法）:
C13H11NO5
CAS号:
分子量:
261.23
Beilstein:
620635
EC號碼:
MDL號碼:
分類程式碼代碼:
51282935
PubChem物質ID:
NACRES:
NA.85
推荐产品
品質等級
溶解度
0.5 M NaOH: soluble 50 mg/mL
抗生素活性譜
Gram-negative bacteria
作用方式
DNA synthesis | interferes
enzyme | inhibits
儲存溫度
2-8°C
SMILES 字串
CCN1C=C(C(O)=O)C(=O)c2cc3OCOc3cc12
InChI
1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)
InChI 密鑰
KYGZCKSPAKDVKC-UHFFFAOYSA-N
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一般說明
化学结构：喹诺酮
應用
恶喹酸被用于研究大肠杆菌（Escherichia coli）和肠沙门氏菌（Salmonella enterica）中的新型传染性抗性机制qnrA、qnrB、qnrS和aac(6′)Ib-cr。将恶喹酸加入培养基中，可用于分离阴道加德纳菌（Gardnerella vaginalis）。
生化／生理作用
恶喹酸是一种喹诺酮类抗生素。它是一种DNA促旋酶（拓扑异构酶II）抑制剂，可用于研究DNA缠绕和卷曲，并作为多巴胺再摄取抑制剂，用于多巴胺能神经传递过程的研究。
其他說明
5g,25g
保存于密闭容器内，置于干燥通风处。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
J S Thompson
Journal of clinical microbiology, 21(5), 843-843 (1985-05-01)
Colistin-oxolinic acid medium is proposed as a selective isolation medium for Gardnerella vaginalis. The medium is effective in inhibiting staphylococci and gram-negative bacteria while allowing growth of G. vaginalis.
J Garcia de Mateos-Verchere et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 8(4), 255-259 (1999-02-03)
The antimicrobial agent oxolinic acid, injected i.p. in mice, induced a dose dependent increase in locomotor activity. This stimulation culminated at the 32 mg/kg dose and became smaller for higher doses (64-128 mg/kg). When opposed to increasing doses (50-100-200 microg/kg
Xiuhong Wang et al.
The Journal of antimicrobial chemotherapy, 65(3), 520-524 (2010-01-14)
Quinolone-mediated death of Escherichia coli has been proposed to occur by two pathways. One is blocked by inhibitors of protein synthesis; the other is not. It is currently unknown how these two pathways fit with the recent observation that hydroxyl
Hyeok Ran Kwon et al.
Pest management science, 66(6), 634-639 (2010-02-13)
Pine wilt disease (PWD) is very complex and has been reported to be caused by pine wood nematode, Bursaphelenchus xylophilus (Steiner & Buhrer) Nickle, and its accompanying bacteria. However, there is no report on the control of PWD by antibacterial
Kalliopi C Skyrianou et al.
Journal of inorganic biochemistry, 104(2), 161-170 (2009-11-27)
The mononuclear nickel(II) complexes with the first-generation quinolone antibacterial agent oxolinic acid in the presence or absence of nitrogen-donor heterocyclic ligands (2,2'-bipyridine, 1,10-phenanthroline or pyridine) have been synthesized and characterized. The experimental data suggest that oxolinic acid acts as deprotonated
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