N3136

纳曲酮的甲醇溶液 盐酸盐

≥99% (HPLC), powder, opioid receptor antagonist

• 别名: Naltrexone HCl
• 经验公式（希尔记法）: C₂₀H₂₃NO₄ · HCl
• CAS号: 16676-29-2
• 分子量: 377.86
• Beilstein: 3580333
• EC號碼: 240-723-0
• MDL號碼: MFCD00069324
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24278051
• NACRES: NA.77

属性

• product name: 纳曲酮的甲醇溶液 盐酸盐,
• 形狀: powder
• 起源: Novartis
• 儲存溫度: 2-8°C
• SMILES 字串: Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6
• InChI: 1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
• InChI 密鑰: RHBRMCOKKKZVRY-ITLPAZOVSA-N
• 基因資訊: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

说明

應用

Naltrexone hydrochloride has been used:

• as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
• to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
• in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

生化／生理作用

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

特點和優勢

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves