所有图片(1)
About This Item
经验公式（希尔记法）:
C27H21N3O5
CAS号:
分子量:
467.47
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
生物来源
Nonomuraea longicatena
质量水平
方案
≥98% (HPLC)
表单
solid
溶解性
DMF: 1 mg/mL
DMSO: 1 mg/mL
抗生素抗菌谱
viruses
作用机制
enzyme | inhibits
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
InChI
1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
InChI key
KOZFSFOOLUUIGY-SOLYNIJKSA-N
基因信息
human ... NTRK1(4914)
rat ... Prkca(24680)
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应用
K-252a 已被用于：
- 作为原肌球蛋白受体激酶（Trk）抑制剂用于研究大鼠中TrkA信号传导的作用
- 作为诱发视网膜Müller神经胶质细胞体外损伤的Trk抑制剂用于研究脐血清（ CBS）的作用
- 作为通用蛋白激酶抑制剂用于研究其对体外 人睾丸体细胞（somatic testicular cell）重组的作用
生化/生理作用
K-252a是酪氨酸蛋白激酶的选择性抑制剂。它的作用对象是IC50值在3 和25nM之间 的多种蛋白激酶以及神经营养因子受体-原肌球蛋白受体激酶。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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