I7284

Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat

affinity isolated antibody, lyophilized powder

• 别名: Anti-CD127, Anti-Il7r
• MDL编号: MFCD01864808
• UNSPSC代码: 51111800
• NACRES: NA.41

属性

• 生物来源: goat
• 质量水平: 100
• 偶联物: unconjugated
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: lyophilized powder
• 种属反应性: mouse
• 技术: flow cytometry: 3.0-10.0 μg/mL; western blot: 0.1-0.2 μg/mL
• UniProt登记号: P16872
• 储存温度: −20°C
• 基因信息: mouse ... Il7r(16197)

说明

一般描述

Interleukin-7 (IL-7) is a stromal-cell derived cytokine that is important in the development of adaptive immunity and maintenance of T cells and B cells. The cognate receptor that binds IL-7 is the IL-7 receptor complex, made up of IL-7 R α (CD127) chain and a γ chain. The expression of IL-7 R is restricted to immature B cells, mature T cells and thymocytes. The binding of IL-7 to its receptor triggers a variety of tightly regulated signaling pathways that are critical for cell survival, proliferation, differentiation and uptake of glucose. The signaling pathways that participate in mediating the effects of IL-7 R are JAK/STAT and PI3K. Additionally, the effect of IL-7 on cell cycle is due to the modulation of proteins p27^kip1 and Cdc25A. Reports implicate IL-7 R in glucose metabolism and cell size as it modulates the effects of GLUT4. Anti-interleukin-7 receptor α/CD127 recognizes mouse IL-7 Rα. This antibody shows less than 1% cross reactivity with rhIL-7 Rα.

免疫原

purified, NSO cell-derived recombinant mouse interleukin-7 soluble receptor α.

应用

Anti-interleukin-7 receptor α/CD127 antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For flow cytometry, the recommended concentration is 3-10 μg/ml/⁶ cells.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

安全信息

• 储存分类代码: 13 - Non Combustible Solids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type N95 (US)