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I100

Sigma-Aldrich

5-碘代杀结核菌素

≥85%, solid

别名:

4-氨基-5-碘-7-吡咯并 [2,3-D] 嘧啶, 5-碘胸苷, 7-碘-7-脱氮腺苷

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About This Item

经验公式（希尔记法）:
C11H13IN4O4
CAS号:
24386-93-4
分子量:
392.15
MDL编号:
MFCD00055131
UNSPSC代码:
12352202
PubChem化学物质编号:
329815331
NACRES:
NA.77

质量水平

100

方案

≥85%

表单

solid

储存温度

2-8°C

SMILES字符串

Nc1ncnc2n(cc(I)c12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

InChI

1S/C11H13IN4O4/c12-4-1-16(10-6(4)9(13)14-3-15-10)11-8(19)7(18)5(2-17)20-11/h1,3,5,7-8,11,17-19H,2H2,(H2,13,14,15)/t5-,7-,8-,11-/m1/s1

InChI key

WHSIXKUPQCKWBY-IOSLPCCCSA-N

相关类别

一般描述

5-碘代杀结核菌素是一种嘌呤，通过抑制腺苷激酶的功能来调节细胞的腺苷水平。它是p53的激活剂，有利于抑制肿瘤，并可作为潜在的化学治疗剂。5-碘代结核菌素介导的腺苷向单磷酸腺苷（AMP）转化的阻滞可以减轻AMP的抗伤害性感受作用（antinociceptive effect ）。现在正在进行5-碘代结核菌素治疗癫痫症的临床试验测试。
溶解度：在DMSO中为10 mg/mL

应用

5-碘胸腺嘧啶已被用于抑制视网膜母细胞瘤细胞、星形胶质细胞培养物和抑制人脐静脉内皮细胞 (HUVEC) 中的腺苷激酶。

生化/生理作用

5-碘铁调素可增加肝细胞的脂肪酸氧化活性和糖原合成。5-碘铁调素也是脑内腺苷摄取的强效抑制剂。
脑内腺苷摄取、腺苷激酶及其后腺嘌呤核苷酸代谢的强效抑制剂。在培养的大鼠肝细胞中，5-碘杀结核菌素抑制乙酰辅酶 a 羧化酶和脂肪酸及胆固醇的从头合成。

注意

溶液可冷冻储存。解冻后及时使用，避免光照。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL1797
BCCJ3820
BCCH5495
BCCF5797
BCCD7512

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