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生物源
synthetic (organic)
品質等級
化驗
≥99% (TLC)
形狀
powder
mp
273 °C
溶解度
water: 50 mg/mL
SMILES 字串
Cl[H].N\N=C1/N=NC=C2C=CC=CC12
InChI
1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;
InChI 密鑰
SECXUXOCDLQOBI-MKFZHGHUSA-N
基因資訊
human ... MAOA(4128) , MAOB(4129)
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應用
盐酸肼屈嗪已用于：
- 研究其作为血管扩张药，对大鼠幼鼠T细胞频率升高相关高血压的影响
- 研究其作为氨基脲敏感性胺氧化酶(SSAO)抑制剂，对心肌缺血再灌注(I/R)损伤的影响
- 研究其作为血管扩张药，对胰岛素分泌和葡萄糖耐受的影响
生化／生理作用
盐酸肼屈嗪(Hydralazine)可用于治疗心力衰竭和高血压。
抑制DNA甲基转移酶并调节基因表达的表观遗传调控。非选择性MAO-A/B抑制剂；降压药；氨基脲敏感性胺氧化酶抑制剂。
特點和優勢
该化合物收录于受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢》页面。想要浏览手册的其他页面， 请单击此处。
訊號詞
Danger
危險分類
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
其他客户在看
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Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin
Waste tea residue as a low cost adsorbent for removal of hydralazine hydrochloride pharmaceutical pollutant from aqueous media: An environmental remediation
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While clinical observations have confirmed a link between the development of neurodegenerative diseases and traumatic brain injuries (TBI), there are currently no treatments available and the underlying mechanisms remain elusive. In response, we have developed an in vitro pendulum trauma
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Sildenafil inhibits cyclic GMP-specific phosphodiesterase type-5A (PDE5A) and can prevent cardiac hypertrophy and left ventricular (LV) dysfunction in mice subjected to severe pressure-overload. The pathophysiological role of sildenafil in adverse remodeling in the hypertensive heart after chronic renin-angiotensin aldosterone system
Mara Colzani et al.
ChemMedChem, 11(16), 1778-1789 (2016-02-19)
Reactive carbonyl species (RCS) are endogenous or exogenous byproducts involved in the pathogenic mechanisms of different oxidative-based disorders. Detoxification of RCS by carbonyl quenchers is a promising therapeutic strategy. Among the most studied quenchers are aminoguanidine, hydralazine, pyridoxamine, and carnosine;
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