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Merck
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文件

F8929

Sigma-Aldrich

氟康唑

≥98% (HPLC), powder, fungal cytochrome P-450 sterol C-14 α-demethyllation inhibitor

别名:

2-(2,4-二氟苯基)-1,3-双(1H-1,2,4-三唑-1-基)丙-2-醇

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About This Item

经验公式（希尔记法）:
C13H12F2N6O
CAS号:
86386-73-4
分子量:
306.27
MDL號碼:
MFCD00274549
分類程式碼代碼:
12352200
PubChem物質ID:
24724485
NACRES:
NA.77

product name

氟康唑, ≥98% (HPLC), powder

化驗

≥98% (HPLC)

形狀

powder

溶解度

DMSO: 5 mg/mL

抗生素活性譜

fungi

作用方式

enzyme | inhibits

儲存溫度

room temp

SMILES 字串

FC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1

InChI

1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2

InChI 密鑰

RFHAOTPXVQNOHP-UHFFFAOYSA-N

基因資訊

human ... CYP1A2(1544)

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一般說明

氟康唑用于治疗中性细胞减少症成人患者的侵袭性假丝酵母菌病(IC)。

應用

氟康唑已用于评估最低抑菌浓度(MIC)-真菌检测。它还被用作植物抗真菌检测的阳性对照。

生化／生理作用

氟康唑是一种抗真菌剂。是真菌细胞色素P-450甾醇C-14α-去甲基化的高选择性抑制剂。氟康唑是一种有效的CYP2C9抑制剂。氟康唑可干扰真菌麦角甾醇合成并下调金属硫蛋白基因。

特點和優勢

该化合物是ADME Tox研究的特色产品。点击此处 了解更多ADME Tox的特色产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Aquatic Chronic 3 - Lact. - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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Current antifungal drugs and immunotherapeutic approaches as promising strategies to treatment of fungal diseases
Nami S, et al.
Biomedicine and Pharmacotherapy, 110, 857-868 (2019)
Screening of selected medicinal plants for their antifungal properties
Aboh MI, et al.
African Journal of Clinical and Experimental Microbiolog, 20(1), 54-59 (2019)
Synthesis, structures and antimicrobial activity of novel NHC-and Ph3P-Ag (I)-Benzoate derivatives
O Beirne C, et al.
Inorgorganica Chimica Acta, 486, 294-303 (2019)
Maiken Cavling Arendrup et al.
Antimicrobial agents and chemotherapy, 53(4), 1628-1629 (2009-02-04)
The fluconazole MIC distributions for Candida glabrata from testing 34 different clinical isolates and performing 51 tests on a single isolate mirrored each other. Since what is perceived as biological variation in isolates without resistance mechanisms is mainly methodological variation
A-C L Meyer et al.
Tropical medicine & international health : TM & IH, 18(4), 495-503 (2013-02-02)
To test the hypothesis that a screening and treatment intervention for early cryptococcal infection would improve survival among HIV-infected individuals with low CD4 cell counts. Newly enrolled patients at Family AIDS Care and Education Services (FACES) in Kenya with CD4 ≤ 100
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