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Merck

D5676

Sigma-Aldrich

N -去甲基氯氮平

别名:

8-氯-11-哌嗪基-5H-二苯并 [b,e] \ [1,4] 二氮嗪, 去甲氯氮平, 去甲甲基氯氮平

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About This Item

经验公式(希尔记法):
C17H17ClN4
CAS号:
分子量:
312.80
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

形狀

powder

品質等級

藥物控制

regulated under CDSA - not available from Sigma-Aldrich Canada

SMILES 字串

Clc1ccc2Nc3ccccc3C(=Nc2c1)N4CCNCC4

InChI

1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2

InChI 密鑰

JNNOSTQEZICQQP-UHFFFAOYSA-N

基因資訊

human ... KCNH1(3756)

應用

本文以 N-去甲基氯氮平为标准,对中国难治性精神分裂症患者的氯氮平血药浓度进行了定量测定。

生化/生理作用

N-去甲基氯氮平是毒蕈碱型乙酰胆碱受体的激动剂,已知具有抗精神病作用。它通过拮抗突触内 GABA(γ-氨基丁酸)受体阻止突触传递。
氯氮平的主要代谢产物;有效的 5-HT 2 5-羟色胺受体拮抗剂和克隆的 5-HT 6 和 5-HT 7 5-羟色胺受体的配体。也是 M 1 毒蕈碱受体的变构增效剂。

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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