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化驗
≥98% (HPLC)
形狀
solid
顏色
light yellow
溶解度
DMSO: ~20 mg/mL
H2O: insoluble
起源
GlaxoSmithKline
儲存溫度
2-8°C
SMILES 字串
NC(=O)c1ccc(cc1)-c2nc(-c3ccccn3)c([nH]2)-c4ccc5OCCOc5c4
InChI
1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
InChI 密鑰
DPDZHVCKYBCJHW-UHFFFAOYSA-N
應用
D4476 has been used as a casein kinase I inhibitor (CKI) in various experiments.
生化/生理作用
D4476 may prevent or enhance apoptosis. It triggers tumor suppressor p53 and impairs transcription factor E2F-1.
D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1).
特點和優勢
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Serine 235 is the primary NS5A hyperphosphorylation site responsible for hepatitis C virus replication
Journal of Virology, 91(14), e00194-e00117 (2017)
Molecular and cellular biology, 36(7), 1124-1135 (2016-01-27)
Wnt pathway-driven proliferation and renewal of the intestinal epithelium must be tightly controlled to prevent development of cancer and barrier dysfunction. Although type I interferons (IFN) produced in the gut under the influence of microbiota are known for their antiproliferative
CK1alpha suppresses lung tumour growth by stabilizing PTEN and inducing autophagy
Nature Cell Biology, 20(4), 465-465 (2018)
Phosphorylation of serine 235 of the hepatitis C virus non-structural protein NS5A by multiple kinases
PLoS ONE, 11(11), e0166763-e0166763 (2016)
CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability
The Journal of biological chemistry, 284(47), 32384-32394 (2009)
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