所有图片(1)
About This Item
经验公式（希尔记法）:
C20H26O4
CAS号:
分子量:
330.42
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.25
推荐产品
生物源
Rosemarinus officinalis L.
品質等級
形狀
powder
應用
metabolomics
vitamins, nutraceuticals, and natural products
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O
InChI
1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
InChI 密鑰
XUSYGBPHQBWGAD-PJSUUKDQSA-N
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一般說明
卡诺醇(CAR)是一种邻二酚二萜，提取自地中海草本植物迷迭香(Rosmarinus officinalis L. )。它最初是从鼠尾草(Sage)植物中分离出来的。卡诺醇也是亲电子分子。
應用
卡诺醇已被用作一种抗癌剂：
- 测试其对肿瘤干细胞样细胞(CSC)和多形性成胶质细胞瘤 (GBM)细胞
- 的抗癌及抗增殖作用，以在人类宫颈癌模型中，检测其对不同遗传致癌途径上、下调节的19个基因以及对海拉细胞的抗癌作用
- 作为参考标准品，采用液相色谱-串联质谱(LC/ESI-MS/MS)对迷迭香提取物的代谢物进行鉴定和定量
生化／生理作用
麝香醇和鼠尾草酸(CA)的抗氧化活性占迷迭香叶的90%。在慢性应激条件下，它具有神经保护特性，可以防止神经炎症和氧化应激诱导的脑损伤。卡诺醇是一种强效化疗药物，研究用于多种类型的癌症，如乳腺癌、白血病、皮肤癌、前列腺癌和结肠癌。它也可用作抗菌剂。
一种具有抗氧化和抗癌活性的酚类二萜。
訊號詞
Warning
危險聲明
危險分類
Skin Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Marcos Roberto de Oliveira
Molecular neurobiology, 53(9), 6155-6168 (2016-11-01)
Carnosic acid (CA) and carnosol are the major diterpenes found in Rosmarinus officinalis (rosemary), a culinary spice. CA and carnosol account for over 90 % of its anti-oxidant activity in rosemary leaves. The diterpenes exert anti-oxidant, anti-inflammatory, and anti-carcinogenic activities, and
The anticancer molecular mechanism of Carnosol in human cervical cancer cells: An in vitro study
Hafidha RR and Abdulamirb AS
Asia-Pacific Journal of Molecular Biology and Biotechnology, 88-98 (2020)
Lucia Cattaneo et al.
PloS one, 10(7), e0132439-e0132439 (2015-07-16)
Rosemary (Rosmarinus officinalis L.) has been used since ancient times in traditional medicine, while nowadays various rosemary formulations are increasingly exploited by alternative medicine to cure or prevent a wide range of health disorders. Rosemary's bioproperties have prompted scientific investigation
Saeed Samarghandian et al.
BMC complementary and alternative medicine, 17(1), 249-249 (2017-05-06)
Oxidative stress through chronic stress destroys the brain function. There are many documents have shown that carnosol may have a therapeutic effect versus free radical induced diseases. The current research focused the protective effect of carnosol against the brain injury
Trude Rakel Balstad et al.
Molecular nutrition & food research, 55(2), 185-197 (2010-09-10)
Cytoprotective gene products, e.g. phase II - and antioxidant enzymes, are important in cellular redox homeostasis. A common feature of these genes is binding sites for transcription factor nuclear factor erythroid-2-related factor 2 (Nrf2), named electrophile response elements (EpREs) within
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