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C8655

Sigma-Aldrich

4-氯-L-苯基丙氨酸

别名:

L-PCPA

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About This Item

线性分子式:
ClC6H4CH2CH(NH2)CO2H
CAS号:
14173-39-8
分子量:
199.63
Beilstein:
2416150
EC號碼:
238-023-5
MDL號碼:
MFCD00063065
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
24893091
NACRES:
NA.32

形狀

powder

品質等級

200

mp

263 °C (dec.) (lit.)

儲存溫度

−20°C

SMILES 字串

N[C@@H](Cc1ccc(Cl)cc1)C(O)=O

InChI

1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1

InChI 密鑰

NIGWMJHCCYYCSF-QMMMGPOBSA-N

基因資訊

human ... TPH1(7166) , TPH2(121278)
mouse ... TPH1(21990) , TPH2(216343)
rat ... TPH1(24848) , TPH2(317675)

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應用

4-氯-L-苯丙氨酸(L-PCPA)已用于：
  • 抑制色氨酸羟化酶(TPH)，从而抑制血清素合成
  • 研究其对癫痫狒狒 (Papio papio)行为和脑电图的影响
  • 作为紫色色杆菌Chromobacterium violaceum苯丙氨酸羟化酶的底物
  • 培养海胆胚胎以便进行免疫组化分析

生化／生理作用

4-氯-L-苯丙氨酸（L-PCPA，L-对氯苯丙氨酸）可抑制5-羟色胺合成。对氯苯丙氨酸(PCPA)可抑制色氨酸羟化酶活性从而降低血清素水平。研究表明对氯苯丙氨酸具有抗野百合碱诱导的肺血管重构和抗肺炎保护作用。
色氨酸羟化酶抑制剂。

包裝

无底玻璃瓶。内含物装在锥底内插管中。

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儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Mechanism of metal-independent hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase
Carr RT, et al.
Biochemistry, 34(22), 7525-7532 (1995)
Behavioural and electrographic effects of L-5-hydroxytryptophan and D, L-parachlorophenyl-alanine on epileptic Senegalese baboon (Papio papio)
Wada JA, et al.
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血清素合成及代谢

血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。

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