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Merck

C8352

Sigma-Aldrich

Anti-CXCR4 (Fusin) (182-196) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41
价格与库存信息目前不能提供

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

IgG fraction of antiserum

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

human

技術

western blot: 0.5-1 μg/mL using human HeLa cell extract

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... CXCR4(7852)

一般說明

Chemokine receptor CXCR-4 also refers as fusin or LESTR is a protein that belongs to G-protein coupled receptor 1 family. It is an essential cofactor for T cell-tropic HIV viruses into CD4+ cells. N-Terminal domain and second extracellular loop of the protein act as a HIV binding sites. Anti-CXCR4 (Fusin) (182-196) antibody can be used to block HIV-1 and HIV-2 fusion and infection of human target cells. Rabbit anti-CXCR4 (Fusin) (182-196) antibody reacts specifically with human CXCR4.

免疫原

synthetic peptide corresponding to amino acids 182-196 of the second extracellular loop of human CXCR4.

應用

Anti-CXCR4 (Fusin) (182-196) antibody may be used in immunoblotting at a working antibody concentration of 0.5 - 1 μg/ml using human HeLa cell extract. It can also be used in immunohistochemistry.

其他說明

The antigen (receptor) is also termed fusin, LESTER and HUMSTR.

外觀

Solution in phosphate buffered saline containing 0.02% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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Karin Jennbacken et al.
The Prostate, 72(8), 913-924 (2012-01-31)
Tasquinimod (ABR-215050) is an orally active quinoline-3-carboxamide analog that has completed phase II clinical trial in patients with castration resistant prostate cancer, showing promising inhibiting effects on the occurrence of metastasis and delayed disease progression. Its mechanism of action is
Raji R Nair et al.
NPJ aging and mechanisms of disease, 4, 9-9 (2018-09-06)
One of the major pathological outcomes of DNA damage during aging or anticancer therapy is enhanced inflammation. However, the underlying signaling mechanism that drives this is not well understood. Here, we show that in response to DNA damage, ubiquitously expressed
Z Lu et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(12), 6426-6431 (1997-06-10)
The chemokine receptor CXCR4 functions as a fusion coreceptor for T cell tropic and dual-tropic HIV-1 strains. To identify regions of CXCR4 that are important for coreceptor function, CXCR4-CXCR2 receptor chimeras were tested for the ability to support HIV-1 envelope
Verena Schwartz et al.
FEBS letters, 583(17), 2749-2757 (2009-08-12)
MIF is a chemokine-like inflammatory mediator that triggers leukocyte recruitment by binding to CXCR2 and CXCR4. MIF also interacts with CD74/invariant chain, a single-pass membrane-receptor. We identified complexes between CD74 and CXCR2 with a role in leukocyte recruitment. It is
M Loetscher et al.
The Journal of biological chemistry, 269(1), 232-237 (1994-01-07)
Several chemotactic agonists including interleukin-8 (IL-8) and related cytokines have been shown to activate and attract leukocytes via seven-transmembrane domain, GTP-binding protein-coupled receptors. A cDNA clone, LESTR, encoding a protein of 352 amino acids, corresponding to a novel receptor of

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