推荐产品
生物源
mouse
品質等級
共軛
unconjugated
抗體表格
ascites fluid
抗體產品種類
primary antibodies
無性繁殖
DCS-6, monoclonal
分子量
antigen 36 kDa (several lower and higher molecular weight bands)
包含
15 mM sodium azide
物種活性
rat, mouse, human, monkey
技術
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:200 using a human tumor cell line extract
同型
IgG2a
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CCND1(595)
mouse ... Ccnd1(12443)
rat ... Ccnd1(58919)
一般說明
抗周期蛋白D1 单克隆抗体(小鼠IgG2a同种型)来自DCS-6杂交瘤,该杂交瘤由小鼠骨髓瘤细胞和免疫小鼠的脾细胞融合产生。周期蛋白 D1 蛋白是哺乳动物细胞G1期周期蛋白。这一蛋白是D型周期蛋白。CCD1基因位于人染色体11q13.3。
特異性
不与其他D型细胞周期蛋白交叉反应。
免疫原
重组人细胞周期蛋白D1蛋白。
應用
小鼠抗周期蛋白 D1 单克隆抗体可用于:
- 免疫印迹
- 免疫荧光
- 免疫细胞化学
- 免疫沉淀
- 免疫组化
- 抗体介导的敲除实验
生化/生理作用
周期蛋白 D1 参与调控周期蛋白依赖性激酶(CDK)家族成员。周期蛋白 D1 和 D2 与CDK4 和/或 CDK6 激酶活性相关,可在G1 期中期观察到,在G1 期后期达到顶峰。在相当比例的癌症中观察到周期蛋白D1 基因扩增,这些癌症包括乳腺癌、膀胱癌、套细胞淋巴瘤、头颈部癌。在食道鳞状细胞癌中也发现这一基因扩增。
外觀
该产品以含有 15mM 叠氮化钠(作为保存剂)的腹水形式提供。
儲存和穩定性
如需连续使用,可在2-8 °C保存至多一月。对于更长期的存储,可对溶液进行等分并冷冻保存。不建议反复冻融。不建议储存在无霜冰箱中。如果长期储存时出现轻微浑浊,请在使用前通过离心澄清溶液。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
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