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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
fractionated antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
rat, mouse, human
濃度
~1 mg/mL
技術
western blot: 5-10 μg/mL using rat brain tissue lysate
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CACNB1(782)
mouse ... Cacnb1(12295)
rat ... Cacnb1(50688)
一般說明
The gene CACNB1 (Calcium channel voltage-dependent subunit β 1) is mapped to human chromosome 17q11.2-q22.
免疫原
synthetic peptide derived from the rat β1 calcium channel conjugated to KLH.
應用
Anti-Calcium Channel (β1 subunit) antibody produced in rabbit is suitable for western blot at a concentration of 5-10 μg/mL using rat brain tissue lysate
生化／生理作用
The CACNB1 (Calcium channel voltage-dependent subunit β 1) is an intracellular regulatory subunit of voltage-activated calcium channels that has significant impact on membrane expression and electrophysical characteristics of the channel. Calcium channel β subunits regulate voltage-dependent calcium currents through direct interaction with α1 subunits. CACNB1 is a target of miRNA-328. In mouse model, CACNB1 is involved in gene expression in muscle progenitor cells and regulates skeletal muscle mass during embryonic development by suppressing myogenin.
外觀
Solution in phosphate buffered saline containing 0.08% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
Jackson Taylor et al.
The Journal of cell biology, 205(6), 829-846 (2014-06-18)
Voltage-gated calcium channel (Cav) β subunits are auxiliary subunits to Cavs. Recent reports show Cavβ subunits may enter the nucleus and suggest a role in transcriptional regulation, but the physiological relevance of this localization remains unclear. We sought to define
Yanjie Lu et al.
Circulation, 122(23), 2378-2387 (2010-11-26)
A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial electric remodeling associated with profound reduction of L-type Ca(2+) current and shortening of the action potential duration. The possibility that microRNAs (miRNAs) may be involved in this process
Solmaz Etemad et al.
Channels (Austin, Tex.), 8(4), 334-343 (2014-05-31)
Voltage-gated calcium channels regulate gene expression by controlling calcium entry through the plasma membrane and by direct interactions of channel fragments and auxiliary β subunits with promoters and the epigenetic machinery in the nucleus. Mutations of the calcium channel β(4)
R G Gregg et al.
Genomics, 15(1), 185-187 (1993-01-01)
A human clone containing a portion of the gene encoding several isoforms of the beta 1 subunit of voltage-dependent calcium channels was isolated and partially sequenced. The gene was mapped to chromosome 17 using the polymerase chain reaction with oligonucleotides
Xingfu Xu et al.
The Journal of biological chemistry, 286(11), 9677-9687 (2011-01-12)
The β subunits of voltage-gated Ca(2+) channels are best known for their roles in regulating surface expression and gating of voltage-gated Ca(2+) channel α(1) subunits. Recent evidence, however, indicates that these proteins have a variety of Ca(2+) channel-independent functions. For
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