推荐产品
生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
BC-22, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~94 kDa
物種活性
mouse, human, rat, chicken
濃度
~2 mg/mL
技術
indirect ELISA: suitable
microarray: suitable
western blot: 5-10 μg/mL using whole cell extract of cultured human 293 cells treated with proteasome inhibitor MG132
同型
IgG2b
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pSer33/pSer37)
基因資訊
human ... CTNNB1(1499)
mouse ... Ctnnb1(12387)
rat ... Ctnnb1(84353)
一般說明
CTNNB1 (catenin β 1) gene is mapped to human chromosome 3p21. The encoded protein β-catenin is localized to the nucleus.
特異性
The antibody is inhibited more efficiently by the pSer37 peptide than by the pSer33 peptide and is not inhibited by the nonphosphorylated peptide. It does not detect the unphosphorylated or the Ser33 phosphorylated protein and does not recognize phosphorylated plakoglobin.
免疫原
synthetic phosphopeptide corresponding to the region that contains serines 33 and 37 of human β-catenin.
應用
Monoclonal Anti-phospho-ß-Catenin (pSer33/pSer37) antibody is suitable for:
- indirect ELISA
- microarray
- western blot at a dilution of 5-10μg/mL using whole cell extract of cultured human 293 cells treated with proteasome inhibitor MG132.
生化／生理作用
β-catenin is mapped on the short arm of chromosome 3. It is useful for differential diagnosis of Osteoblastoma (OB) and osteosarcoma (OS). β-catenin signaling pathway may contribute to cholangiocarcinoma (CCA) cell proliferation. It may serve as a prognostic marker for CCA progression and hence can be significant in the CCA therapy target.
In Wnt/β-catenin signal pathway β-Catenin participates as a signal transduction molecule. The pathway is associated with development, tissue homeostasis and oncogenic transcription. Upregulation of the gene is associated with glioma cell proliferation. The protein encoded has dual function that regulates the coordination of cell-cell adhesion by linking cytoskeleton and cellular junctions and gene transcription. Wnt/β-catenin signal pathway is known to induce progression colon cancer progression.
In Wnt/β-catenin signal pathway β-Catenin participates as a signal transduction molecule. The pathway is associated with development, tissue homeostasis and oncogenic transcription. Upregulation of the gene is associated with glioma cell proliferation. The protein encoded has dual function that regulates the coordination of cell-cell adhesion by linking cytoskeleton and cellular junctions and gene transcription. Wnt/β-catenin signal pathway is known to induce progression colon cancer progression.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin.
Leonid A S, et al.
Journal of Cell Science, 130, 1717-1729 (2017)
Simon Megy et al.
FEBS letters, 580(22), 5411-5422 (2006-09-26)
The interaction of the P-beta-Cat(19-44) peptide, a 26 amino acid peptide (K(19)AAVSHWQQQSYLDpSGIHpSGATTTAP(44)) that mimics the phosphorylated beta-Catenin antigen, has been studied with its monoclonal antibody BC-22, by transferred nuclear Overhauser effect NMR spectroscopy (TRNOESY) and saturation transfer difference NMR (STD
Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells.
Sadot E, et al.
Journal of Cell Science, 115(Pt 13), 2771-2780 (2002)
Antibody-based proteomics for esophageal cancer: Identification of proteins in the nuclear factor-KB pathway and mitotic checkpoint.
Uemura N, et al.
Cancer Science, 100(9), 1612-1622 (2009)
Kai Prager et al.
The Journal of biological chemistry, 282(19), 14083-14093 (2007-03-16)
Presenilins (PS) are critical components of the gamma-secretase complex that mediates cleavage of type I membrane proteins including the beta-amyloid precursor protein to generate the amyloid beta-peptide. In addition, PS1 interacts with beta-catenin and facilitates its metabolism. We demonstrate that
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