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Merck
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文件

C3930

Sigma-Aldrich

钙调蛋白抑制剂

solid

别名:

1- [双（4-氯苯基）甲基]-3- [2,4-二氯-β-氯化咪唑, 1- [双（4-氯苯基）甲基]-3- [2-（2,4-二氯苯基）-2-（2,4-二氯苄氧基）乙基]-1H-咪唑氯化物, R 24571

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About This Item

经验公式（希尔记法）:
C31H23Cl7N2O
CAS号:
57265-65-3
分子量:
687.70
Beilstein:
6470244
MDL號碼:
MFCD00077679
分類程式碼代碼:
12352202
PubChem物質ID:
24278023
NACRES:
NA.77

形狀

solid

品質等級

200

顏色

white

儲存溫度

2-8°C

SMILES 字串

[Cl-].Clc1ccc(cc1)C(c2ccc(Cl)cc2)[n+]3ccn(CC(OCc4ccc(Cl)cc4Cl)c5ccc(Cl)cc5Cl)c3

InChI

1S/C31H23Cl6N2O.ClH/c32-23-6-1-20(2-7-23)31(21-3-8-24(33)9-4-21)39-14-13-38(19-39)17-30(27-12-11-26(35)16-29(27)37)40-18-22-5-10-25(34)15-28(22)36;/h1-16,19,30-31H,17-18H2;1H/q+1;/p-1

InChI 密鑰

YGEIMSMISRCBFF-UHFFFAOYSA-M

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生化／生理作用

钙调素调节酶抑制剂。它也被认为可以直接阻断平滑肌细胞的钙通道。

注意

在水溶液中与玻璃表面结合。

重構

可用 DMSO 制备 5 mM 储备液，然后用缓冲液稀释至 0.01 mM。DMSO 溶液可储存数周。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Helle Jensen et al.
Molecular immunology, 53(3), 255-264 (2012-09-12)
In this study we demonstrate that histone deacetylase (HDAC)-inhibitor mediated cell surface expression of the structural different NKG2D-ligands MICA/B and ULBP2 is calcium-dependent. Treatment with the calcium chelator EGTA inhibited constitutive as well as HDAC-inhibitor induced MICA/B and ULBP2 cell
Qi Xi et al.
American journal of physiology. Heart and circulatory physiology, 301(2), H428-H433 (2011-05-17)
Glutamate-stimulated, astrocyte-derived carbon monoxide (CO) causes cerebral arteriole dilation by activating smooth muscle cell large-conductance Ca(2+)-activated K(+) channels. Here, we examined the hypothesis that glutamate activates heme oxygenase (HO)-2 and CO production via the intracellular Ca(2+) concentration ([Ca(2+)](i))/Ca(2+)-calmodulin signaling pathway
Shi-Hong Gu et al.
Journal of insect physiology, 56(1), 93-101 (2009-10-06)
Our previous studies showed that the prothoracicotropic hormone (PTTH) stimulated extracellular signal-regulated kinase (ERK) phosphorylation in prothoracic glands of Bombyx mori both in vitro and in vivo. In the present study, the signaling pathway by which PTTH activates ERK phosphorylation
Ming Lu et al.
The Journal of endocrinology, 208(1), 31-39 (2010-10-27)
Intracellular calcium ([Ca(2+)](i)) is the most relevant modulator of parathyroid hormone (PTH) secretion. Uniquely, an increase in [Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways. The ubiquitous calcium-binding proteins, calmodulin
Virender Singh et al.
Molecular pharmaceutics, 15(8), 3356-3368 (2018-07-07)
Huntington's disease (HD) is a genetic disorder caused by a CAG expansion mutation in Huntingtin gene leading to polyglutamine (polyQ) expansion in the N-terminus side of Huntingtin (Httex1) protein. Neurodegeneration in HD is linked to aggregates formed by Httex1 bearing
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