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Merck

C2615

Sigma-Aldrich

色原烷醇293B

≥98% (HPLC), powder

别名:

反式-N-[6-氰基-3,4-二氢-3-羟基-2,2-二甲基-2H-1-苯并吡喃-4-基]-N-甲基-乙磺酰胺

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About This Item

经验公式(希尔记法):
C15H20N2O4S
分子量:
324.40
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white

溶解度

DMSO: 18 mg/mL

儲存溫度

−20°C

SMILES 字串

CCS(=O)(=O)N(C)[C@@H]1[C@@H](O)C(C)(C)Oc2ccc(cc12)C#N

InChI

1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1

InChI 密鑰

HVSJHHXUORMCGK-UONOGXRCSA-N

一般說明

色原烷醇293B对映体是钾通道蛋白(KvLQT1)的一种有效抑制剂。在人心房肌细胞中,色原烷醇293B可抑制复极钾电流。色原烷醇293B可通过调节钾电压门控通道(KCNQ1)而改善胰腺中葡萄糖刺激的胰岛素分泌(GSIS)。

應用

色原烷醇293B已用于抑制人上皮细胞系中钙和环腺苷一磷酸(cAMP)激活的钾通道。色原烷醇293B已用于心肌细胞的膜片钳电生理学研究。

生化/生理作用

通过KCNQ1通道阻断慢延迟整流器K+

特點和優勢

该化合物在受体分类和信号转导手册的钾通道页面上有重点介绍。想要浏览手册的其他页面, 请单击此处

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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访问文档库

CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels
Jantarajit W, et al.
American Journal of Physiology. Cell Physiology, 313(1), C118-C129 (2017)
Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels
Yang IC, et al.
Journal of Pharmacology and Experimental Therapeutics, 294(3), 955-962 (2000)
A Varro et al.
The Journal of physiology, 523 Pt 1, 67-81 (2000-02-16)
1. The relative contributions of the rapid and slow components of the delayed rectifier potassium current (IKr and IKs, respectively) to dog cardiac action potential configuration were compared in ventricular myocytes and in multicellular right ventricular papillary muscle and Purkinje
J E Matos et al.
Acta physiologica (Oxford, England), 189(3), 251-258 (2007-02-20)
Colonic crypts are the site of Cl- secretion. Basolateral K+ channels provide the driving force for luminal cystic fibrosis transmembrane regulator-mediated Cl- exit. Relevant colonic epithelial K+ channels are the intermediate conductance Ca2+-activated K(Ca)3.1 (SK4) channel and the cAMP-activated K(V)7.1
Chromanol 293B, an inhibitor of KCNQ1 channels, enhances glucose-stimulated insulin secretion and increases glucagon-like peptide-1 level in mice
Liu L, et al.
Islets, 6(4), e962386-e962386 (2014)

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