C240
8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphorothioate, Rp Isomer triethylammonium salt
≥98% (HPLC), solid
别名:
Rp-8-CPT-cGMPS, Rp-8-[(4-Chlorophenyl)thio]-cGMPS triethylammonium salt, Rp-8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3′,5′-hydrogen phosphorothioate triethylammonium salt
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所有图片(1)
About This Item
经验公式（希尔记法）:
C16H15ClN5O6PS2 · C6H15N
CAS号:
分子量:
605.07
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.77
推荐产品
生物源
synthetic
品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
white
溶解度
H2O: 5 mg/mL
儲存溫度
−20°C
SMILES 字串
CCN(CC)CC.NC1=Nc2c(nc(Sc3ccc(Cl)cc3)n2[C@@H]4O[C@@H]5CO[P@@](O)(=S)O[C@H]5[C@H]4O)C(=O)N1
InChI
1S/C16H15ClN5O6PS2.C6H15N/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(27-14)5-26-29(25,30)28-11;1-4-7(5-2)6-3/h1-4,8,10-11,14,23H,5H2,(H,25,30)(H3,18,20,21,24);4-6H2,1-3H3/t8-,10-,11-,14-,29-;/m1./s1
InChI 密鑰
KVOYZBYGWGWWTD-TXBWCVORSA-N
生化／生理作用
Rp-8-CPT-cGMP is a potent inhibitor of protein kinase G Ia, Ib, and type II.
特點和優勢
This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
聯結
8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphorothioate, Rp Isomer triethylammonium salt is more cell permeable than Rp-cGMPS triethylamine.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
S AbdAlla et al.
European journal of biochemistry, 241(2), 498-506 (1996-10-15)
The hormone-induced depletion of cellular Ca stores provides a signal for the Ca2+ influx into electrically non-excitable cells; however, the underlying molecular mechanisms remain elusive. Therefore, we analyzed bradykinin-activated Ca2+ influx into human foreskin fibroblast cells, HF-15, by fura-2 and
E Butt et al.
European journal of pharmacology, 269(2), 265-268 (1994-10-14)
In the present study, the inhibitory effect of the cGMP analog (Rp)-8-(para-chlorophenylthio)guanosine-3',5'-cyclic monophosphorothioate ((Rp)-8-pCPT-cGMPS) on the cGMP-dependent protein kinase-mediated protein phosphorylation in intact human platelets was investigated. In vitro phosphorylation experiments with the substrate kemptide demonstrated an inhibition of the
J Pineda et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 16(4), 1389-1399 (1996-02-15)
Nitric oxide (NO) and carbon monoxide (CO) have been identified as two diffusible signaling messengers in the brain, capable of stimulating soluble guanylate cyclase. Locus coeruleus (LC) is rich in the alpha 1 and beta 1 subunits of soluble guanylate
C Mathes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 16(5), 1702-1709 (1996-03-01)
Inward currents activated by 8-bromc-cGMP and by muscarinic agonist were compared in N1E-115 mouse neuroblastoma cells using perforated-patch voltage clamp and Fura-2 imaging. The cGMP analog activates a voltage-independent inward current that is carried at least in part by Ca2+
Jia-Shuan Wu et al.
Oncotarget, 8(25), 40906-40921 (2017-04-14)
Chemotherapy of brain glioma faces a major obstacle owing to the inability of drug transport across the blood-brain barrier (BBB). Besides, neovasculatures in brain glioma site result in a rapid infiltration, making complete surgical removal virtually impossible. Herein, we reported
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