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生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
HL1499 (6D4-3F4-6C4), monoclonal
形狀
buffered aqueous solution
物種活性
rabbit, rat, mouse, human
技術
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 3-6 μg/mL using total extract from rat kidney
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CASR(846)
mouse ... Casr(12374)
rat ... Casr(24247)
一般說明
The calcium sensing receptor (CASR) gene with 11 exons is mapped to human chromosome 3q13.33-q21.1. CASR is a member of the C family of G protein–coupled receptors and is mainly localized in the parathyroid gland and the thick ascending limb of the Henle loop. CASR is a 1078 amino acid protein.
免疫原
peptide corresponding to amino-acids 15-29 at the extracellular N-terminus of calcium sensing receptor.
應用
Monoclonal Anti-Calcium Sensing Receptor antibody produced in mouse is suitable for the following applications:
- Indirect ELISA
- Immunoblotting
- Immunocytochemistry
- Immunohistochemistry (formalin-fixed, paraffin-embedded sections)
- Western blotting at a concentration of 3-6μg/mL using total extract from rat kidney
Monoclonal anti-calcium sensing receptor antibody produced in mouse has been used in western blotting and immunohistochemistry.
生化／生理作用
Calcium sensing receptor (CASR) regulates cell activity according to the extracellular calcium concentration. It also plays a major role in controlling parathyroid hormone (PTH) secretion. Thus, this protein can be considered as a potent target for therapeutic agents designed to modify parathyroid gland function. CASR has a role in key signal transduction pathways in several tissues such as parathyroid gland, kidney, gastrointestinal tract, placenta, pancreas and brain. Mutation in the gene is associated with autosomal dominant hypocalcemic, hypercalciuria and Bartter syndrome.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease
Gardenal E, et al.
Frontiers in Neuroscience (2017)
Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells
Vaz CV, et al.
Biochimica et Biophysica Acta, 1853, 2621-2628 (2015)
Calcium-Sensing Receptors
Goodman WG, et al.
Seminars in Nephrology, 24, 17-24 (2004)
Genetic Risk Factors for Idiopathic Urolithiasis: A Systematic Review of the Literature and Causal Network Analysis.
Taguchi K, et al.
European eurology focus, 3, Taguchi K-Taguchi K (2017)
Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease.
Emanuela G, et al.
Frontiers in Neuroscience, 2017 -2017 null
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