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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 345 kDa
物種活性
mouse (predicted), rat (predicted), human
濃度
~1 mg/mL
技術
immunoprecipitation (IP): 5-10 μg using HEK 293-T cell lysates
microarray: suitable
western blot: 2-4 μg/mL using U2OS total cell extracts
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TP53BP1(7158)
mouse ... Trp53bp1(27223)
rat ... Tp53bp1(296099)
一般說明
Tumor protein p53 binding protein (T153BP1) is mapped to human chromosome 15q15.3. It has methylated histone-binding module and tandem tudor domains.
免疫原
synthetic peptide corresponding to amino acids 1955-1972 of human 53BP1, conjugated to KLH via an N-terminal added cysteine residue. This sequence is conserved in mouse, and differs from rat by one amino acid
應用
Anti-53BP1 (C-terminal) antibody produced in rabbit has been used in western blotting and immunoprecipitation
生化／生理作用
Tumor protein p53 binding protein (T153BP1) has a close link to ataxia-telangiectasia mutated (ATM)-regulated events. 53BP1 becomes phosphorylated by ATM in a DNA damage-dependent manner suggesting that it participates in propagating the ATM signaling to its downstream effectors. T153BP1 also plays a key role in DNA repair by mediating nonhomologous end-joining (NHEJ) near double stranded breaks (DSBs). Fusion of T153BP1 with platelet-derived growth factor receptor beta (PDGFRβ) is implicated in a type of myeloproliferative disorder accompanied with eosinophilia.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Genomic landscape of liposarcoma
Kanojia D, et al.
Testing, 6(40), 42429-42429 (2015)
Role of 53BP1 oligomerization in regulating double-strand break repair
Lottersberger F, et al.
Proceedings of the National Academy of Sciences of the USA, 110(6), 2146-2151 (2013)
Michael T Perfetti et al.
ACS chemical biology, 10(4), 1072-1081 (2015-01-16)
Improving our understanding of the role of chromatin regulators in the initiation, development, and suppression of cancer and other devastating diseases is critical, as they are integral players in regulating DNA integrity and gene expression. Developing small molecule inhibitors for
p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with at (5; 15)(q33; q22) and an imatinib-responsive eosinophilic myeloproliferative disorder
Grand FH, et al.
Cancer Research, 64(20), 7216-7219 (2004)
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
Botuyan MV, et al.
Cell, 127(7), 1361-1373 (2006)
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