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應用
氨磷汀可以使用生长抑素类似物减轻辐射损伤并减少吸收的肾脏辐射剂量,从而在PRRT期间提供肾脏保护。氨磷汀可补救辐射对鼠下颌骨矿化能力的退化作用。
生化/生理作用
辐射防护剂。选择性地保护正常组织免受抗肿瘤放射疗法的破坏作用。选择性归因于正常组织的优先摄取以及随后对2-(3-氨基丙基)氨基乙硫醇的代谢活化。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Human reproduction (Oxford, England), 27(8), 2457-2466 (2012-05-18)
In a previous study, we found that amifostine provides some protection to the seminiferous epithelium of prepubertal doxorubicin-treated male rats but does not improve their fertility status as adults. Based on these results, a long-term study was undertaken to evaluate
The Cochrane database of systematic reviews, 5(5), CD009219-CD009219 (2012-05-18)
Platinum-based therapy, including cisplatin, carboplatin and/or oxaliplatin, is used to treat a variety of paediatric malignancies. Unfortunately, one of the most important adverse effects is the occurrence of hearing loss or ototoxicity. In an effort to prevent this ototoxicity, different
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(5), 749-753 (2012-04-13)
Megalin-mediated renal retention of radiolabeled somatostatin analogs may lead to nephrotoxicity during peptide receptor radionuclide therapy (PRRT). The cytoprotective agent amifostine protected rats from long-term nephrotoxicity after PRRT with (177)Lu-DOTA,Tyr(3)-octreotate. This study describes the direct effect of amifostine on kidney
Drugs, 50(6), 1001-1031 (1995-12-01)
Amifostine (WR-2721) was originally developed as a radioprotective agent. In animals, it protects normal tissues from the damaging effects of irradiation and, as shown in more recent studies, of several cytotoxic agents. Protection of tumours is generally reduced compared with
Low-dose antioxidant is sufficient to regulate pulmonary redox equilibration.
Critical care medicine, 40(5), 1693-1694 (2012-04-19)
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