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About This Item
经验公式（希尔记法）:
C15H20O3
CAS号:
分子量:
248.32
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.25
推荐产品
生物源
Atractylodes macrocephala Koidz.
化驗
≥98% (HPLC)
形狀
powder or crystals
顏色
white to off-white
溶解度
methanol: 1 mg/mL, clear, colorless
應用
metabolomics
vitamins, nutraceuticals, and natural products
儲存溫度
2-8°C
SMILES 字串
CC1=C2C[C@H]3C(=C)CCC[C@]3(C)C[C@]2(O)OC1=O
InChI
1S/C15H20O3/c1-9-5-4-6-14(3)8-15(17)12(7-11(9)14)10(2)13(16)18-15/h11,17H,1,4-8H2,2-3H3/t11-,14+,15-/m0/s1
InChI 密鑰
FBMORZZOJSDNRQ-GLQYFDAESA-N
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一般說明
Atractylenolide III is a biologically active sesquiterpene compound, extracted from the roots of Atractylodes macrocephala Koidzumi.
應用
Atractylenolide III has been used to examine its effects on the energy metabolism in the skeletal muscles of mouse.
Atractylenolide III, a sesquiterpenoid, is a phytochemical that may be used to study its anti-inflammatory and anti-angiogenesis activities. Atractylenolide III may be used and studied as an inhibitor of aromatases and inducer of apoptosis. Atractylenolide III may be used to study its sonic hedgehog pathway dependent mechanism of action as an inducer of chondrogenic differentiation. Atractylenolide III may be used as a reference material in assays to detect its presence in plant root extracts and biological milieu such as plasma.
生化／生理作用
Atractylenolide III has been shown to possess anti-inflammatory effects and also offers gastroprotection. It also shows acaricidal properties and hence has the potential to be used as an agent for the control of dust mites. Atractylenolide III is capable of regulating the secretion and expression of Interleukin-6, thereby mediating the immune response caused by mast cells.
Atractylenolide III possesses anti-inflammatory and anticancer properties.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Kun-Teng Wang et al.
The Journal of pharmacy and pharmacology, 62(3), 381-388 (2010-05-22)
The rhizome of Atractylodes ovata De Candolle is popularly used in traditional Chinese medicine to treat gastrointestinal diseases. However, the major gastroprotective compounds of A. ovata have not been identified. This study reports on the principal gastro- protective component of
Hyun-Kyung Kim et al.
Journal of agricultural and food chemistry, 55(15), 6027-6031 (2007-06-28)
The acaricidal activity of materials derived from rhizome of Atractylodes ovata (Atractylodes macrocephala) toward adult Dermatophagoides farinae and Dermatophagoides pteronyssinus was examined using fabric-circle residual contact and vapor-phase toxicity bioassays. Results were compared with those of the currently used acaricides:
Yue Qiu et al.
Evidence-based complementary and alternative medicine : eCAM, 2019, 1392020-1392020 (2020-01-18)
Gastroesophageal reflux disease (GERDs) is a common chronic digestive system disease, in which the symptoms of reflux esophagitis (RE) seriously affect the quality of life. We aimed to study the therapeutic effect of Zhujie Hewei granules (ZHG) on reflux esophagitis
Xican Li et al.
Biological & pharmaceutical bulletin, 35(8), 1328-1335 (2012-08-07)
Molecules that enhance chondrogenic differentiation in mesenchymal stem cells (MSCs) were identified and isolated using an in vitro Gli reporter gene assay in MSCs incorporating a Sonic Hedgehog (Shh) target. Atractylenolide III, which promoted Gli1-mediated transcriptional activity, was isolated from
Seung-Hyun Jeong et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1126-1127, 121743-121743 (2019-08-12)
The purpose of this study was to develop a method for simultaneous analysis of fourteen major active components in Gumiganghwal-tang tablet widely prescribed for cold related diseases using UPLC-ESI-MS/MS. Twelve of these 14 components were separated using 0.1% formic acid
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