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A1755

Sigma-Aldrich

Aminophylline dihydrochloride hyderate

≥98%, powder

别名:

(Theophylline)2 · Ethylenediamine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1), Theophylline hemiethylenediamine complex

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About This Item

经验公式（希尔记法）:
C7H8N4O2 · 0.5C2H8N2
CAS号:
317-34-0
分子量:
210.21
EC號碼:
206-264-5
MDL號碼:
MFCD00013221
分類程式碼代碼:
41106305
PubChem物質ID:
24277691
NACRES:
NA.77

化驗

≥98%

形狀

powder

顏色

white to off-white

溶解度

H2O: 50 mg/mL (solutions should be freshly prepared.)
alcohol: insoluble

儲存溫度

−20°C

SMILES 字串

NCCN.CN1C(=O)N(C)c2nc[nH]c2C1=O.CN3C(=O)N(C)c4nc[nH]c4C3=O

InChI

1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2

InChI 密鑰

FQPFAHBPWDRTLU-UHFFFAOYSA-N

基因資訊

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

應用

Aminophylline has been used:
  • as a positive control in the selective inhibitor of nuclear export, KPT-350 zebrafish dosing experiments
  • as a positive control for the determination of the spasmolytic activity of C. aeruginosa extracts
  • as a phosphodiesterase (PDE) inhibitor in inhibitor studies to quantify its potency to inhibit PDE4A1A and PDE3A enzyme in an assay

生化／生理作用

Aminophylline is a methylxanthine compound containing theophylline andethylenediamine in a ratio of 2:1. It acts as a bronchodilator and is used to treat chronic lung diseases like asthma, bronchitis, or emphysema.
Non-selective phosphodiesterase (PDE) inhibitor. Antiepileptic drug

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Saniyya Khan et al.
Journal of biomolecular structure & dynamics, 39(3), 970-976 (2020-01-30)
Aminophylline (Am) is a methylxanthine compound clinically applied for chronic lung diseases like asthma, bronchitis or emphysema. Chemically, it comprises theophylline and ethylenediamine in a ratio 2:1. For the widening of the therapeutic window of any class of drug or
K C Crisanti et al.
The American journal of physiology, 277(3 Pt 2), R829-R835 (1999-09-14)
In newborns and adults of a number of species, exposure to acute hypoxemia produces a "regulated" decrease in core temperature, the mechanism of which is unknown. The present experiments were carried out on chronically instrumented newborn (5-10 days of age;
Antiasthmatic effect of Curcuma aeruginosa extract on isolated organ of the trachea
Marliana E, et al.
F1000Research (2018)
Ram Manohar Basnet et al.
BMC pharmacology & toxicology, 18(1), 72-72 (2017-11-17)
Zebrafish embryos are emerging as a model for pharmacological and toxicological studies. We used zebrafish embryos to study the general toxicity and cardiovascular effects of eight methylxanthines: aminophylline, caffeine, diprophylline, doxofylline, etophylline, 3-isobutyl-1-methylxanthine (IBMX), pentoxifylline and theophylline. Microinjections of the
Danieli Barino Salinas et al.
Pediatric research, 87(1), 137-145 (2019-07-26)
There is a need to prognosticate the severity of cystic fibrosis (CF) detected by newborn screening (NBS) by early assessment of CF transmembrane conductance regulator (CFTR) protein function. We introduce novel instrumentation and protocol for evaluating CFTR activity as reflected
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