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Merck
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Key Documents

360R-1

Sigma-Aldrich

Hemoglobin A (EPR3608) Rabbit Monoclonal Primary Antibody

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

EPR3608, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (360R-14)
vial of 0.5 mL concentrate (360R-15)
bottle of 1.0 mL predilute (360R-17)
vial of 1.0 mL concentrate (360R-16)
bottle of 7.0 mL predilute (360R-18)

製造商/商標名

Cell Marque

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

同型

IgG

控制

bone marrow, placenta

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

cytoplasmic

一般說明

Hemoglobin alpha chain belongs to the globin family and is involved in oxygen transport from the lung to the various peripheral tissues. Hemoglobin A is comprised of two alpha chains and two beta chains, whereas hemoglobin A2 is comprised of two alpha chains and two delta chains. Immunohistochemical localization of hemoglobin is excellent as an erythroid marker for the detection of immature, dysplastic, and megaloblastic erythroid cells in myeloproliferative disorders, such as erythroleukemia. In contrast, myeloid cells, lymphoid cells, plasma cells, histiocytes, and megakaryocytes stain negative with anti-hemoglobin A. Anti-hemoglobin A, combined with antibodies against CD34, CD117, CD68, and MPO can be helpful in distinguishing between reactive extramedullary hematopoiesis and that seen in neoplastic myeloid disorders in spleen. Anti-hemoglobin A is limited to expression by erythroid precursors in bone marrow and is therefore of assistance in calculating percentages of erythroid precursors.

品質


IVD

IVD

IVD

RUO

聯結

HEMOGLOBIN A Positive Control Slides, Product No. 360S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

準備報告

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Dennis P O'Malley et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 18(12), 1550-1561 (2005-08-25)
Spleen is a common site of extramedullary hematopoiesis. Extramedullary hematopoiesis seen in non-neoplastic conditions can occasionally be extensive and raise concerns for a myeloid neoplasm. We compared the morphologic and immunohistochemical features of splenic hematopoietic proliferations seen in neoplastic myeloid
Cherie H Dunphy et al.
Applied immunohistochemistry & molecular morphology : AIMM, 15(2), 154-159 (2007-05-26)
Accurate bone marrow (BM) blast counts (BCs) are essential for diagnosis (dx) of myelodysplasia (MDS), MDS/myeloproliferative (MDS/MPD) disease, or acute myeloid leukemia (AML), and may be difficult in hemodiluted bone marrow aspirates (BMAs). Erythroid precursors (EPs) may be indistinguishable from

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