推荐产品
生物源
rabbit
品質等級
100
500
共軛
unconjugated
抗體表格
Ig fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
形狀
buffered aqueous solution
物種活性
human
包裝
vial of 0.1 mL concentrate (262A-14)
vial of 0.5 mL concentrate (262A-15)
bottle of 1.0 mL predilute (262A-17)
vial of 1.0 mL concentrate (262A-16)
bottle of 7.0 mL predilute (262A-18)
製造商／商標名
Cell Marque™
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
控制
ALCL, spleen
運輸包裝
wet ice
儲存溫度
2-8°C
視覺化
cytoplasmic
基因資訊
human ... GZMB(3002)
一般說明
Granzymes are serine proteases which are stored in specialized lytic granules of cytotoxic T-lymphocytes and in natural killer cells. Anti-granzyme B has been useful in diagnosing natural killer/T-cell lymphoma, as well as anaplastic large cell lymphoma. High percentages of cytotoxic T-cells have been shown to be an unfavorable indicator in Hodgkin disease.
品質
 IVD |  IVD |  IVD |  RUO |
聯結
Granzyme B Positive Control Slides, Product No. 262S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外觀
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
準備報告
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他說明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律資訊
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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J A Kummer et al.
Clinical and experimental immunology, 100(1), 164-172 (1995-04-01)
Cytoplasmic granules from activated natural killer (NK) and cytotoxic T lymphocytes (CTL) contain a pore-forming protein, perforin, and several homologous serine proteinases called granzymes. Expression of these proteins correlates with the cytolytic potential of cytotoxic lymphocytes. Using a panel of
Naoko Kato et al.
The American Journal of dermatopathology, 25(2), 142-147 (2003-03-26)
A neutrophil-rich anaplastic large cell lymphoma (ALCL) presented in the skin of a 47-year-old Japanese woman. The solitary cutaneous lesion was an eroded, 10-mm, dome-shaped nodule involving the skin of her left upper arm. Histologically, it showed a proliferation of
J J Oudejans et al.
The American journal of pathology, 148(1), 233-240 (1996-01-01)
Reed-Sternberg (RS) and Hodgkin's (H) cells are considered to be the neoplastic cells in Hodgkin's disease. Although most data suggest a lymphoid origin, the nature of these cells still remains the subject of considerable controversy. Recently, monoclonal antibodies became available
J J Oudejans et al.
Blood, 89(4), 1376-1382 (1997-02-15)
Although the results of treatment of Hodgkin's disease (HD) have improved considerably in the last decades, the disease remains fatal in a minority of patients. We have recently shown that numbers of activated cytotoxic T cells (CTLs), present in tumor
Jie Liu et al.
The Journal of dermatology, 30(10), 735-741 (2003-12-20)
Nasal natural killer (NK)/T cell lymphoma is an Epstein-Barr virus (EBV) associated lymphoma that arises in the nasal area and aggressively invades surrounding tissues. Our patient was a 48-year-old male who had had nasal obstruction and nasal discharge for 2
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