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Merck

100-05A

Sigma-Aldrich

Human Dermal Microvascular Endothelial Cells: CADMEC/HMVEC, adult

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About This Item

分類程式碼代碼:
41106514
NACRES:
NA.81

生物源

human neonatal foreskin or adult skin capillaries (normal)

品質等級

包裝

pkg of 500,000 cells

製造商/商標名

Cell Applications, Inc

增長模式

Adherent

染色體組型

2n = 46

形態學

Endothelial

技術

cell culture | mammalian: suitable

運輸包裝

dry ice

儲存溫度

−196°C

一般說明

Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details.

CADMEC/HMVEC provide an excellent model system to study many aspects of endothelial function and disease, especially those related to the microvasculature and capillary systems. HMVEC/CADMEC have been shown to express vWF, CD36 and CD31, are able to uptake DiI-Ac-LDL and are positive for functional activity by cytokine-stimulated leukocyte adherence.

Select HMVEC lots have been additionally tested to demonstrate stimulation-dependent angiogenesis and key endothelial cell signaling pathways (phosphorylation of VEGFR, Akt, MAPK, and expression of Tie2, eNOS, Axl and Etk/Bmx).

細胞系來源

Skin

應用

Endothelial vessel function, cell signaling, angiogenesis

成分

Cell Basal Medium containing 10% FBS & 10% DMSO

準備報告

  • 2nd passage, >500,000 cells in Cell Basal Medium containing 10% FBS & 10% DMSO
  • Can be cultured at least 16 doublings

例行更新培養

Please refer to the CADMEC/HMVEC Culture Protocol.

免責聲明

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Steven E Reid et al.
The EMBO journal, 36(16), 2373-2389 (2017-07-12)
Tumor progression alters the composition and physical properties of the extracellular matrix. Particularly, increased matrix stiffness has profound effects on tumor growth and metastasis. While endothelial cells are key players in cancer progression, the influence of tumor stiffness on the

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