Y0001691

伊马替尼 甲磺酸酯

European Pharmacopoeia (EP) Reference Standard

• 别名: 4-[(4-甲基-1-哌嗪基)甲基]-N-[4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯基]苯甲酰胺 甲磺酸酯, 4-[(4-甲基哌嗪-1-基)甲基]-N-(4-甲基-3-{[4-(吡啶-3-基)嘧啶-2-基]氨基}苯基)苯甲酰胺 甲磺酸酯, CGP 57148, STI-571, 伊马替尼 甲磺酸酯, 格列卫, 甲磺酸伊马替尼
• 经验公式（希尔记法）: C₂₉H₃₁N₇O · CH₄O₃S
• CAS号: 220127-57-1
• 分子量: 589.71
• 分類程式碼代碼: 41116107
• NACRES: NA.24

属性

• 等級: pharmaceutical primary standard
• API 家族: imatinib
• 製造商／商標名: EDQM
• 應用: pharmaceutical (small molecule)
• 格式: neat
• 儲存溫度: 2-8°C
• InChI: 1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)
• InChI 密鑰: YLMAHDNUQAMNNX-UHFFFAOYSA-N

说明

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Imatinib mesilate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化／生理作用

甲磺酸伊马替尼是一种具有抗肿瘤活性的酪氨酸激酶抑制剂。伊马替尼能够抑制由bcr-abl致癌基因编码的Bcr-Abl激酶以及由c-kit和血小板源性生长因子受体（PDGFR）致癌基因编码的受体酪氨酸激酶。甲磺酸伊马替尼通过抑制由CML中费城染色体异常产生的Bcr-Abl酪氨酸激酶，降低了白血病CML和ALL的增殖并诱导其凋亡。 在过度表达c-kit的疾病中，如胃肠道间质瘤（GIST），通过抑制c-kit酪氨酸活性，可抑制肥大细胞和细胞增殖。

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

安全信息

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H361d
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Repr. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable