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Merck
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文件

Y0000772

莫昔克丁

European Pharmacopoeia (EP) Reference Standard

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About This Item

经验公式（希尔记法）:
C37H53NO8
CAS号:
113507-06-5
分子量:
639.82
MDL號碼:
MFCD00866560
分類程式碼代碼:
41116107
PubChem物質ID:
329831142
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

moxidectin

製造商／商標名

EDQM

應用

pharmaceutical (small molecule)

格式

neat

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

CO\N=C1/C[C@]2(C[C@@H]3CC(C\C=C(C)\C[C@@H](C)\C=C\C=C4/COC5[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]45O)O2)O[C@@H]([C@H]1C)\C(C)=C\C(C)C

InChI

1S/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31+/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1

InChI 密鑰

YZBLFMPOMVTDJY-LSGXYNIPSA-N

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相关类别

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Moxidectin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

象形圖

Skull and crossbonesEnvironment
GHS06,GHS09

訊號詞

Danger

危險聲明

H301,H400

危險分類

Acute Tox. 3 Oral - Aquatic Acute 1

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

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分析证书(COA)

Lot/Batch Number

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Atul Awasthi et al.
Profiles of drug substances, excipients, and related methodology, 38, 315-366 (2013-05-15)
Moxidectin or F28249α is a potent endectocide and semisynthetic methoxime derivative of naturally occurring nemadectin. It is well known for the novel mode of action against a broad range of nematode and anthropod animal parasites. In this work, physicochemical and
Extralabel use of ivermectin and moxidectin in food animals.
R E Baynes et al.
Journal of the American Veterinary Medical Association, 217(5), 668-671 (2000-09-08)
Meenakshi Verma et al.
Folia parasitologica, 61(6), 561-570 (2015-02-06)
Moxidectin is a macrocyclic lactone belonging to milbemycin family closely related to ivermectin and is currently progressing towards Phase III clinical trial against human infection with the filaria Onchocerca volvulus (Leuckart, 1894). There is a single report on the microfilaricidal
Till F Omansen et al.
PLoS neglected tropical diseases, 9(3), e0003549-e0003549 (2015-03-06)
Mycobacterium ulcerans causes Buruli ulcer (BU), a debilitating infection of subcutaneous tissue. There is a WHO-recommended antibiotic treatment requiring an 8-week course of streptomycin and rifampicin. This regime has revolutionized the treatment of BU but there are problems that include
Bob Storey et al.
International journal for parasitology. Drugs and drug resistance, 4(3), 233-243 (2014-12-18)
A major hindrance to evaluating nematode populations for anthelmintic resistance, as well as for screening existing drugs, new compounds, or bioactive plant extracts for anthelmintic properties, is the lack of an efficient, objective, and reproducible in vitro assay that is

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