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Merck

Y0000479

氯丙嗪杂质D

European Pharmacopoeia (EP) Reference Standard

别名:

Desmethylchlorpromazine, 3-(2-Chloro-10H-phenothiazin-10-yl)-N-methylpropan-1-amine

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About This Item

经验公式(希尔记法):
C16H17ClN2S
CAS号:
分子量:
304.84
分類程式碼代碼:
41116107
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

chlorpromazine

製造商/商標名

EDQM

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

InChI

1S/C16H17ClN2S/c1-18-9-4-10-19-13-5-2-3-6-15(13)20-16-8-7-12(17)11-14(16)19/h2-3,5-8,11,18H,4,9-10H2,1H3

InChI 密鑰

YHFXGBOUSIKGMZ-UHFFFAOYSA-N

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Chlorpromazine impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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G Alfredsson et al.
Acta psychiatrica Scandinavica. Supplementum, 311, 49-74 (1984-01-01)
Schizophrenic patients were treated with fixed doses of sulpiride (800 mg) or chlorpromazine (400 mg) during eight weeks using a double-blind design. In order to examine relationships between pharmacokinetic, clinical and biochemical parameters in relation to treatment the following variables
M Chetty et al.
Therapeutic drug monitoring, 13(4), 350-355 (1991-07-01)
The concentrations of chlorpromazine (CPZ) and six of its metabolites in patient plasma samples that had been stored for 24 h at -20 degrees C, for 1 week at -20 degrees C, and for 4 weeks at -70 degrees C
G P Sgaragli et al.
Bollettino della Societa italiana di biologia sperimentale, 60(9), 1757-1763 (1984-09-30)
Nanogram amounts of chlorimipramine, chlorpromazine and their Nor1- and Nor2-metabolites were detected in plasma by GLC with nitrogen-sensitive detection. Two extraction procedures were compared. The use of Sep Pak C18 cartridges produced a higher degree of accuracy and precision with
R C Young
Therapeutic drug monitoring, 8(1), 23-26 (1986-01-01)
Plasma nor1-chlorpromazine (nor1-CPZ) and chlorpromazine concentrations were measured by gas chromatography--mass fragmentometry in 15 inpatients receiving stable doses of chlorpromazine. Nor1-CPZ concentrations averaged 20% of chlorpromazine concentrations and were highly correlated with them. Relative concentrations of nor1-CPZ increased with age.
R Ninci et al.
Journal of chromatography, 381(2), 315-322 (1986-09-05)
A gas chromatographic method using nitrogen-selective detection for the quantitative determination of nanogram amounts of chlorimipramine, chlorpromazine and their nor1 and nor2 derivatives in plasma is described. Derivatization with trifluoroacetic anhydride of nor1 and nor2 metabolites allowed the chromatographic separation

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