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Merck

Y0000297

美沙拉嗪

European Pharmacopoeia (EP) Reference Standard

别名:

5-氨基水杨酸, 5-AS, 5-氨基-2-羟基苯甲酸, 氨水杨酸

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About This Item

线性分子式:
H2NC6H3-2-(OH)CO2H
CAS号:
分子量:
153.14
Beilstein:
2090421
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

mesalamine, mesalazine

製造商/商標名

EDQM

mp

275-280 °C (dec.) (lit.)

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

Nc1ccc(O)c(c1)C(O)=O

InChI

1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)

InChI 密鑰

KBOPZPXVLCULAV-UHFFFAOYSA-N

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一般說明

本品按现行药典规定交付。所有为支持本产品而提供的信息,包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持,请访问现行药典网站。

應用

5-氨基水杨酸是适用于ELISA分析的过氧化物酶底物。这一底物产生可溶性的棕色终产物,可在450nm处通过分光光度法读取。使用3 N NaOH可终止反应并在550 nm处读取结果。

包裝

本品按照现行药典要求提供。有关当前单位数量,请见EDQM 参考目录

其他說明

可能适用相应的销售限制条件。

相關產品

产品编号
说明
价格

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

No data available

閃點(°C)

No data available


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Morris Gordon et al.
The Cochrane database of systematic reviews, (1)(1), CD008414-CD008414 (2011-01-21)
The use of 5-aminosalicylates (5-ASAs) in Crohn's disease (CD) is controversial.  A recent Cochrane review found that 5-ASAs are not effective for the maintenance of medically-induced remission in CD, but their role in the maintenance of surgically-induced remission is unclear.
P Desreumaux et al.
Alimentary pharmacology & therapeutics, 24 Suppl 1, 2-9 (2006-08-31)
The effectiveness of sulfasalazine depends on the splitting of the diazo bond in the molecule by the action of bacteria in the large bowel, releasing the pharmacologically active moiety, 5-aminosalicylic acid. The development of pH-dependent, delayed-release formulations of 5-aminosalicylic acid
Roja Rahimi et al.
Digestive diseases and sciences, 54(4), 712-721 (2008-08-07)
5-Aminosalicylates are the standard treatment for induction and maintenance of remission in mild-to-moderate ulcerative colitis. In recent years, the 5-aminosalicylic acid-containing pro-drug balsalazide has been the focus of attention. To compare the efficacy and tolerance of balsalazide and mesalazine by
Alexander C Ford et al.
The American journal of gastroenterology, 106(12), 2070-2077 (2011-09-07)
Maintenance therapy with 5-aminosalicylates (5-ASAs) is recommended in patients with quiescent ulcerative colitis (UC), but compliance rates are low. Once-daily dosing may improve adherence, but impact on the relapse of disease activity is unclear as no previous meta-analysis has studied
A B Hawthorne et al.
Alimentary pharmacology & therapeutics, 27(12), 1157-1166 (2008-04-04)
Significant number of patients with ulcerative colitis (UC) fail to comply with treatment. To review issues surrounding medication non-adherence in inflammatory bowel disease (IBD), including the clinical and health service implications in the UK, and discuss strategies for optimizing medication

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