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Merck

PHR1319

Supelco

残留溶剂-三氯乙烯

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

三氯乙烯, TCE, 三氯代乙烯

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About This Item

线性分子式:
ClCH=CCl2
CAS号:
分子量:
131.39
Beilstein:
1736782
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:

等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

traceable to USP 1601827

蒸汽密度

4.5 (vs air)

蒸汽壓力

61 mmHg ( 20 °C)

CofA

current certificate can be downloaded

自燃溫度

770 °F

技術

HPLC: suitable
gas chromatography (GC): suitable

折射率

n20/D 1.476 (lit.)

bp

86.7 °C (lit.)

mp

−84.8 °C (lit.)

密度

1.463 g/mL at 25 °C (lit.)

應用

pharmaceutical (small molecule)

格式

single component solution

儲存溫度

2-30°C

SMILES 字串

Cl\C=C(\Cl)Cl

InChI

1S/C2HCl3/c3-1-2(4)5/h1H

InChI 密鑰

XSTXAVWGXDQKEL-UHFFFAOYSA-N

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一般說明

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Residual Solvent - Trichloroethylene belongs to the group of class 2 residual solvents. The use of class 2 solvents should be limited in drug substances, excipients, dietary ingredients, and official products because of the inherent toxicities of these residual solvents. Trichloroethylene is a volatile and chlorinated organic compound, which finds applications as a solvent and greasing agent.

應用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAA0678 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形圖

Health hazard

訊號詞

Danger

危險聲明

危險分類

Carc. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

188.6 °F - closed cup

閃點(°C)

87 °C - closed cup


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分析证书(COA)

Lot/Batch Number

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其他客户在看

Hideaki Watanabe
The Journal of dermatology, 38(3), 229-235 (2011-02-24)
The number of patients suffering from trichloroethylene (TCE)-related severe skin disorders with liver dysfunction has been increasing in developing countries in Asia, especially since the mid-1990s. In Japan, five cases of this disease have been reported, but none since the
Yih-Horng Shiao
Environmental and molecular mutagenesis, 50(1), 68-77 (2008-11-26)
Trichloroethylene (TCE), an organic solvent commonly used for metal degreasing and as a chemical additive, is a significant environmental contaminant that poses health concerns in humans. The US Environmental Protection Agency (EPA) is currently revising the 2001 TCE human risk
Berit Bakke et al.
Journal of occupational and environmental hygiene, 4(5), 375-390 (2007-04-25)
This article describes a systematic review of the industrial hygiene literature for uses of trichloroethylene (TCE) in industry for the exposure assessment of two population-based case control studies of brain cancer in the United States. Papers and reports that address
Jane C Caldwell et al.
Environmental and molecular mutagenesis, 49(2), 142-154 (2007-11-02)
The mode(s) of action (MOA) of a pollutant for adverse health effects may be dependent on the mixture of metabolites resulting from exposure to a single agent and may also be affected by coexposure to pollutants that have similar targets
Cheryl Siegel Scott et al.
International journal of environmental research and public health, 8(11), 4238-4272 (2011-12-14)
We conducted a meta-analysis focusing on studies with high potential for trichloroethylene (TCE) exposure to provide quantitative evaluations of the evidence for associations between TCE exposure and kidney, liver, and non-Hodgkin lymphoma (NHL) cancers. A systematic review documenting essential design

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