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Merck
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文件

917419

Sigma-Aldrich

2-(2-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride

别名:

Semi-flexible linker for PROTAC® development

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About This Item

经验公式（希尔记法）:
C13H22Cl2N2
分子量:
277.23
分類程式碼代碼:
12352116
NACRES:
NA.22

形狀

powder

品質等級

100

反應適用性

reagent type: linker

官能基

amine

儲存溫度

2-8°C

SMILES 字串

NCCC1=C(C=CC=C1)C2CCNCC2.Cl.Cl

相关类别

應用

2-(2-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

其他說明

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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