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Merck
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文件

48912-U

Sigma-Aldrich

ProClin™ 300

pkg of 50 mL, ProClin™ preservative for use in IVD manufacturing, CMIT/MIT 3 %

别名:

3% 5-氯-2-甲基-4-异噻唑啉-3-酮和2-甲基-4-异噻唑啉-3-酮溶液

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About This Item

分類程式碼代碼:
12352201
NACRES:
NA.21

形狀

liquid

儲存期限

3 yr

包含

Alkyl Carboxylate

成份

CMIT/MIT, 3%

包裝

pkg of 50 mL

參數

<45 °C operating temperature

顏色

colorless to light yellow

基質

Modified glycol

工作pH值範圍

2.5-8.5

pH值

4.1 (100 g/L)

bp

189 °C

mp

-40 °C

溶解度

water: soluble

密度

1.03 g/cm3

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一般說明

ProClin™ 防腐剂是一种的水溶性杀菌制剂，通常用于延长试剂的保质期。ProClin™ 300 由 3% 的 5-氯-2-甲基-4-异噻唑啉-3-酮(CMIT) 和 2-甲基-4-异噻唑啉-3-酮 (MIT) 组成，溶于含有烷基羧酸盐的无盐专有乙二醇稳定剂中。推荐工作 pH 范围为 2.5 - 8.5。

應用

ProClin™ 300 适用于制备不同的缓冲液，如 ELISA 缓冲液、样品和底物稀释缓冲液，用于单分子阵列（Simoa 分析）和免疫酶分析。此外，ProClin™ 可用于制备储存缓冲液，以储存与冠状病毒核衣壳蛋白偶联的珠子，并用于血清学多重检测。
仅限生物诊断检测和体外诊断检测使用
ProClin™ biocides preservatives are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin™ toxicity prevent microorganisms from developing high levels of resistance, making ProClin™ highly efficient even over extended storage periods of your IVD components.

生化／生理作用

ProClin™ 产品包含例如 CMIT 和 MIT等活性物质，它们可在四个不同的检查点抑制三羧酸循环，分别为丙酮酸脱氢酶、α-酮戊二酸脱氢酶、琥珀酸脱氢酶和NADH脱氢酶。三羧酸循环的抑制可实现对细菌、真菌和酵母的有效广谱杀灭活性。

法律資訊

ProClin is a trademark of LANXESS Corp.

免責聲明

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada′s Pest Management Regulatory Agency, Turkey′s Biocidal Products Regulation, Korea′s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

訊號詞

Danger

危險分類

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

244.4 °F - closed cup

閃點（°C）

118 °C - closed cup

個人防護裝備

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Choose from one of the most recent versions:

分析证书(COA)

Lot/Batch Number
MKCW5719
MKCW1837
MKCV4372
MKCV6710
MKCT2079

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Annika Nelde et al.
Nature immunology, 22(1), 74-85 (2020-10-02)
T cell immunity is central for the control of viral infections. To characterize T cell immunity, but also for the development of vaccines, identification of exact viral T cell epitopes is fundamental. Here we identify and characterize multiple dominant and
Molecular-biological problems of drug design and mechanism of drug action
GI Khvatova and AV Semeikin
Journal of Pharmacy and Chemistry, 44(12), 651-653 (2011)
Single Molecule Arrays for ultra-sensitive detection of rat cytokines in serum
Cohen L, et al.
Journal of Immunological Methods, 452, 20-25 (2018)
Limor Cohen et al.
Journal of immunological methods, 452, 20-25 (2017-10-19)
Rats are used as animal models for many human diseases. Cytokines can serve as biomarkers indicative of these diseases or disease states. Techniques for measuring cytokine expression levels often do not provide the sensitivity needed to measure these biomarkers in
SARS-CoV-2 T-cell epitopes define heterologous and COVID-19-induced T-cell recognition
Nelde A, et al.
Research (Washington, D.C.) (2020)
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