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product name
AT-3 Mouse Mammary Carcinoma Cell Line, AT-3 mouse mammary tumor cell line may be used to develop mouse models for mammary cancer studies.
生物源
mouse
技術
cell culture | mammalian: suitable
運輸包裝
ambient
一般說明
The AT-3 cell line was isolated from an autologous mammary tumor from cells originating in a transgenic MTAG mouse model . Mammary tumors arising in MTAG mice closely mimic changes observed in human breast carcinomas over the course of disease progression . AT-3 cells are a useful mouse model for studies of tumor physiology that are representative of typical disease states in humans.
Source:
The AT-3 cell line was derived from primary mammary tumor cells of a transgenic MTAG mouse. The MTAG mouse model expresses the polyoma virus middle T antigen under control of the MMTV-LTR promoter .
Note: AT-3 cells demonstrate diverse morphologies in culture.
Source:
The AT-3 cell line was derived from primary mammary tumor cells of a transgenic MTAG mouse. The MTAG mouse model expresses the polyoma virus middle T antigen under control of the MMTV-LTR promoter .
Note: AT-3 cells demonstrate diverse morphologies in culture.
Tumor-induced immunosuppression is a common phenomenon in cancer and an important consideration for cancer immunotherapy. However, most studies on tumor-induced immunosuppression rely on tumor implant models, in which the disease progresses rapidly and usually causes non-physiological host responses that do not recapitulate normal tumor development and progression . Models that generate autochthonous tumors are therefore valuable for providing more physiologically-relevant systems for investigating tumor-host interactions and longer-term immunosuppressive effects.
細胞系描述
Cancer Cells
應用
AT-3 mouse mammary tumor cell line may be used to develop mouse models for mammary cancer studies.
Research Category
Cancer
Oncology
Cancer
Oncology
This product is sold solely for research use per the terms of the “Restricted Use Agreement” which govern its use as detailed in the product Data Sheet or Certificate of Analysis. For information regarding any other use, please contact licensing@emdmillipore.com.
品質
• Each vial contains ≥ 1X10⁶ viable cells.
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination
儲存和穩定性
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
免責聲明
This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges {HCompany} to request certain information about you and the establishment where the GMOs are being handled. Click here for Enduser Declaration (EUD) Form.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
Trina J Stewart et al.
Journal of immunology (Baltimore, Md. : 1950), 179(5), 2851-2859 (2007-08-22)
Ag-specific and generalized forms of immunosuppression have been documented in animal tumor models. However, much of our knowledge on tumor-induced immunosuppression was acquired using tumor implant models, which do not reiterate the protracted nature of host-tumor interactions. Therefore, a transgenic
Elaine Y Lin et al.
The American journal of pathology, 163(5), 2113-2126 (2003-10-28)
Animal models are powerful tools to analyze the mechanism of the induction of human breast cancer. Here we report a detailed analysis of mammary tumor progression in one mouse model of breast cancer caused by expression of the polyoma middle
Weijie Zhang et al.
Cell, 184(9), 2471-2486 (2021-04-21)
Metastasis has been considered as the terminal step of tumor progression. However, recent genomic studies suggest that many metastases are initiated by further spread of other metastases. Nevertheless, the corresponding pre-clinical models are lacking, and underlying mechanisms are elusive. Using
Multiphoton Microscopy of FITC-labelled Fusobacterium nucleatum in a Mouse in vivo Model of Breast Cancer.
Parhi, et al.
Bio-protocol, 13, e4635-e4635 (2023)
C T Guy et al.
Molecular and cellular biology, 12(3), 954-961 (1992-03-01)
The effect of mammary gland-specific expression of the polyomavirus middle T antigen was examined by establishing lines of transgenic mice that carry the middle T oncogene under the transcriptional control of the mouse mammary tumor virus promoter/enhancer. By contrast to
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