推荐产品
生物源
mouse
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
C3-33, monoclonal
形狀
liquid
包含
≤0.1% sodium azide as preservative
物種活性
fish, canine, rat, avian, amphibian, rabbit
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
avoid repeated freeze/thaw cycles
同型
IgG1
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
rat ... Ryr2(689560)
一般說明
Mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing splenocytes with P3X 63 AG8.653 mouse myeloma cells (see application references). Supplied as protein G purified antibody. Recognizes the ~565 kDa ryanodine receptor.
Recognizes the ~565 kDa ryanodine receptor in rat brain hippocampus. A ~565 kDa doublet representing the α and β isoforms is observed in non-mammalian vertebrates.
This Anti-Ryanodine Receptor Mouse mAb (C3-33) is validated for use in Frozen Sections, Immunoblotting, Immunoprecipitation for the detection of Ryanodine Receptor.
免疫原
Canine
canine cardiac ryanodine receptor (RYR)
應用
Frozen Sections (1 g/ml, see application references)
Immunoblotting (1 g/ml)
Immunoprecipitation (see comments)
包裝
Please refer to vial label for lot-specific concentration.
警告
Toxicity: Standard Handling (A)
外觀
In PBS.
重構
Following initial thaw, aliquot and freeze (-20°C).
分析報告
Positive Control
Rat brain hippocampus
Rat brain hippocampus
其他說明
A ~565 kDa doublet representing the α and β isoforms is observed in non-mammalian vertebrates. In frozen sections, Clone C3-33 strongly stains the myofiber consistent with the sarcoplasmic reticulum of the RyR. This antibody has been reported to work for immunoprecipitation; the concentration is assay-dependent. Antibody should be titrated for optimal results in individual systems.
Sitsapesan, R., et al. 1995. Trends Pharmacol. Sci.16, 386.
McPherson, P.S. and Campbell, K.P. 1993. J. Biol. Chem.268, 13765.
Meszaros, L.G., et al. 1993. Nature364, 76.
Lai, F.A., et al. 1992. Biochem. J.288, 553.
Lai, F.A., et al. 1989. Nature331, 315.
McPherson, P.S. and Campbell, K.P. 1993. J. Biol. Chem.268, 13765.
Meszaros, L.G., et al. 1993. Nature364, 76.
Lai, F.A., et al. 1992. Biochem. J.288, 553.
Lai, F.A., et al. 1989. Nature331, 315.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Ioannis Smyrnias et al.
Cell calcium, 47(3), 210-223 (2010-01-29)
Narrow, tubular, inward projections of the sarcolemma ('T-tubules') are an established feature of adult mammalian ventricular myocytes that enables them to generate the whole-cell Ca2+ transients and produce coordinated contraction. Loss of T-tubules can occur during ageing and under pathological
Carmen Tarifa et al.
JACC. Basic to translational science, 8(1), 1-15 (2023-02-14)
Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematical
Verónica Jiménez-Sábado et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 158, 114169-114169 (2023-01-03)
Atrial fibrillation (AF) has been associated with excessive spontaneous calcium release, linked to cyclic AMP (cAMP)-dependent phosphorylation of calcium regulatory proteins. Because β-blockers are expected to attenuate cAMP-dependent signaling, we aimed to examine whether the treatment of patients with β-blockers
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