MABT908

Anti-Integrin beta-8 Antibody, clone 6B9

clone 6B9, from mouse

• 别名: ITGB8
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 6B9, monoclonal
• 物種活性: human
• 技術: immunohistochemistry: suitable (paraffin)
• 同型: IgG1κ
• NCBI登錄號: NP_002205
• UniProt登錄號: P26012
• 運輸包裝: ambient
• 目標翻譯後修改: unmodified
• 基因資訊: human ... ITGB8(3696)

说明

一般說明

Integrin beta-8 (UniProt: P26012) is encoded by the ITGB8 gene (Gene ID: 3696) in human. Integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. The integrin receptors are composed of alpha and beta subunits and each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. Integrin beta-8 is a single-pass type I membrane protein that associates with alpha V chain in a non-covalent manner to make a heterodimer that serves as a receptor for vitronectin, fibrin, and the latency associated peptide (LAP). Integrin beta-8 binding to LAP is reported to promote the proteolytic release of active TGF-beta from LAP. Integrin beta-8 contains a VWFA domain and four cysteine-rich repeats. It is required for vascular morphogenesis in the embryonic brain and yolk sac. Higher expression of integrin beta-8 is observed in placenta, kidney, brain, ovary, uterus, and in several transformed cells. It is transiently expressed in 293 human embryonic kidney cells. Higher expression of ITGB8 is linked to high angiogenic and poorly invasive glioblastoma tumors. Conversely, low expression of ITGB8 correlates with highly invasive, but low angiogenic tumors. Higher expression of integrin beta-8 is observed in placenta, kidney, brain, ovary, uterus, and in several transformed cells. It is transiently expressed in 293 human embryonic kidney cells.

特異性

Clone 6B9 detects human integrin beta-8 subunit.

免疫原

A truncated recombinant form of human Integrin B8 corresponding to first 682 amino acids.

應用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Integrin beta-8 in human colon and human placenta tissues.

Research Category
Cell Structure

This mouse monoclonal Anti-Integrin beta-8 Antibody, clone 6B9, Cat. No. MABT908, is tested for use in Immunohistochemistry (Paraffin) for the detection of Integrin beta-8.

品質

Evaluated by Immunohistochemistry in human colon tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Integrin beta-8 in human colon tissue.

標靶描述

85.63 kDa calculated.

外觀

Protein G purified

Format: Purified

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1