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Merck
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Key Documents

MABT78

Sigma-Aldrich

Anti-mouse CD44 (H-CAM) Antibody, clone KM201

clone KM201, from rat

别名:

CD44 antigen (homing function and Indian blood group system), CDw44 antigen, HCAM, H-CAM, HUTCH-1, Phagocytic glycoprotein I, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, Heparan sulfate proteoglycan, Hermes antigen, Hyalu

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rat

品質等級

抗體表格

purified antibody

抗體產品種類

primary antibodies

無性繁殖

KM201, monoclonal

物種活性

mouse

技術

flow cytometry: suitable

同型

IgG1κ

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... CD44(960)

一般說明

CD44, also known as H-CAM is a distinct adhesion molecule that, with its 13 known isoforms, comprises a family of transmembrane glycoproteins involved in a wide variety of significant biological processes. Members belonging to this family are involved in apoptosis, migration, metastasis, tumor progression, lymphocyte homing, and the attachment of hematopoietic cells to stromal cells. CD44 is the primary cell surface receptor for hyaluronic acid (HA), and is also a notable target for WNT signaling within the intestinal mucosa. Recent studies have used CD44 marker as a means to isolate different cancer stem cells (CSC) such as; colorectal CSC, pancreatic CSC, and prostate CSC.

特異性

The antibody recognizes CD44 near the hyaluronate binding domain.

免疫原

Epitope: Near the hyaluronate binding domain
Mouse bone marrow-derived stromal cells

應用

Detect mouse CD44 (H-CAM) using this Anti-mouse CD44 (H-CAM) Antibody, clone KM201 validated for use in FC.
Research Category
Cell Structure

Stem Cell Research
Research Sub Category
Adhesion (CAMs)

Hematopoietic Stem Cells

品質

Evaluated by Flow Cytometry in mouse bone marrow cells.

Flow Cytometry Analysis: 0.1 µg of this antibody detected CD44 in mouse bone marrow cells.

標靶描述

86 kDa calculated

聯結

Replaces: CBL1308

外觀

Protein G
Format: Purified
Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Mouse bone marrow cells

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Giuseppe M Campo et al.
Innate immunity, 19(5), 462-478 (2013-01-04)
Investigations have suggested degradation of native hyaluronan (HA) into small oligosaccharides as being involved in the development and progression of inflammatory diseases, particularly rheumatoid arthritis (RA). Inflammatory responses occur by modulating the TLR4 and 2, and the CD44 natural HA
Monserrat Gerardo-Ramírez et al.
Cells, 12(9) (2023-05-13)
Primary liver cancer is the third leading cause of cancer-related death worldwide. An increasing body of evidence suggests that the Hippo tumor suppressor pathway plays a critical role in restricting cell proliferation and determining cell fate during physiological and pathological

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